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UBP1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9201829

UBP1 functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells… More details

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Product Overview

Online Datasheet in PDF
Product Name
UBP1, Polyclonal Antibody
Full Product Name
UBP1 Antibody (Center)
Product Gene Name
anti-UBP1 antibody
Product Synonym Names
Upstream-binding protein 1; Transcription factor LBP-1; UBP1; LBP1
Clonality
Polyclonal
Isotype
Rabbit Ig
Host
Rabbit
Species Reactivity
Human (Predicted Reactivity: Mouse)
Form/Format
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Purity/Purification
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Concentration
Vial Concentration: 0.5 (lot specific)
Specificity
This UBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-295 amino acids from the Central region of human UBP1.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
Antibody/Peptide Pairs
UBP1 peptide (MBS9220430) is used for blocking the activity of UBP1 antibody (MBS9201829)
Molecular Weight
60491
Immunogen Sequence Positions
266-295
OMIM
609784
3D Structure
ModBase 3D Structure for Q9NZI7
Antigen Type
Synthetic Peptide
Antigen Source
HUMAN
Applications Tested/Suitable for anti-UBP1 antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-UBP1 antibody
IF~~1:10~50
WB~~1:1000

Immunofluorescence (IF) of anti-UBP1 antibody

Fluorescent image of A549 cell stained with UBP1 Antibody (Center). A549 cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with UBP1 primary antibody (1:25, 1 h at 37 degree). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37 degree).Cytoplasmic actin was counterstained with Alexa Fluor 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37 degree).UBP1 immunoreactivity is localized to Nucleus significantly.
Rabbit Anti-UBP1 Polyclonal Antibody – Cat# MBS9201829

Western Blot (WB) of anti-UBP1 antibody

UBP1 Antibody (Center) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the UBP1 antibody detected the UBP1 protein (arrow).
Rabbit Anti-UBP1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS9201829

Immunohistochemistry (IHC) of anti-UBP1 antibody

UBP1 Antibody (Center) (MBS9201829)immunohistochemistry analysis in formalin fixed and paraffin embedded human breast tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of UBP1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-UBP1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9201829

Product References and Citations for anti-UBP1 antibody

Katsura, A., et al. Genes Cells 14(10):1183-1196(2009)
Koutnikova, H., et al. PLoS Genet. 5 (8), E1000591 (2009) :
Henderson, Y.C., et al. DNA Cell Biol. 27(2):71-79(2008)
Huang, N., et al. Mol. Endocrinol. 19(2):409-420(2005)
Huang, N., et al. J. Biol. Chem. 275(4):2852-2858(2000)

Other Notes

Small volumes of anti-UBP1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UBP1 purchase

MBS9201829 is an antibody targeting UBP1. Also known as UBP1 Antibody (Center). Reactive in Human (Predicted Reactivity: Mouse). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for UBP1. It may not necessarily be applicable to this product.

NCBI GI #
189491632
NCBI GeneID
7342
NCBI Accession #
NP_001121632.1
NCBI Related Accession #
NP_001121633.1; NP_055332.3
UniProt Primary Accession #
Q9NZI7
UniProt Secondary Accession #
Q68CT0; Q86Y57; Q9H8V0; Q9UD76; Q9UD78
UniProt Related Accession #
Q9NZI7
GenBank Nucleotide #
NM_001128160.1
NCBI Official Full Name
upstream-binding protein 1 isoform LBP-1a
NCBI Official Synonym Full Names
upstream binding protein 1 (LBP-1a)
NCBI Official Symbol
UBP1
NCBI Official Synonym Symbols
LBP1A; LBP1B; LBP-1B; LBP-1a
UniProt Protein Name
Upstream-binding protein 1
UniProt Synonym Protein Names
Transcription factor LBP-1
Protein Family
Oligouridylate-binding protein
UniProt Gene Name
UBP1
UniProt Synonym Gene Names
LBP1
UniProt Entry Name
UBIP1_HUMAN
NCBI Protein Information
upstream-binding protein 1

UniProt Comments for UBP1

UBP1: Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2. Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box. Belongs to the grh/CP2 family. CP2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 3p22.3

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: DNA binding; sequence-specific DNA binding; transcription factor activity; transcription corepressor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; angiogenesis; viral genome replication; negative regulation of transcription, DNA-dependent
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Research Articles on UBP1

1. Data revealed that dimers composed of LBP-1a and LBP-1c were re-formed probably by a partner-exchange of LBP-1b-containing heterodimers.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-UBP1 antibody

 Reference Product  PubMed Publications
 TFCP2L1 antibody  >4 publications with UBP1 and TFCP2L1
 YY1 antibody  >2 publications with UBP1 and YY1
 CYP11A1 antibody  >2 publications with UBP1 and CYP11A1

Diseases associated with anti-UBP1 antibody

 Disease Name  Pubmed Publications
 Vascular Diseases Antibodies  >1 publications with UBP1 and Vascular Diseases
 Urogenital Abnormalities Antibodies  >1 publications with UBP1 and Urogenital Abnormalities
 Fetal Growth Retardation Antibodies  >1 publications with UBP1 and Fetal Growth Retardation
 Embryo Loss Antibodies  >1 publications with UBP1 and Embryo Loss
 Fetal Death Antibodies  >1 publications with UBP1 and Fetal Death
 Necrosis Antibodies  >1 publications with UBP1 and Necrosis

Organs/Tissues associated with anti-UBP1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with UBP1 and Blood
 Placenta Antibodies  >4 publications with UBP1 and Placenta
 Embryonic Tissue Antibodies  >3 publications with UBP1 and Embryonic Tissue
 Bone Marrow Antibodies  >2 publications with UBP1 and Bone Marrow
 Lung Antibodies  >2 publications with UBP1 and Lung
 Bone Antibodies  >2 publications with UBP1 and Bone
 Connective Tissue Antibodies  >1 publications with UBP1 and Connective Tissue
 Liver Antibodies  >1 publications with UBP1 and Liver
 Skin Antibodies  >1 publications with UBP1 and Skin
 Kidney Antibodies  >1 publications with UBP1 and Kidney
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