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MAZ Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9614283

May function as a transcription factor with dual roles in transcription initiation and termination. Binds to two sites, ME1a1 and ME1a2, within the MYC promoter having greater affinity for the former. Also binds to multiple G/C-rich sites within the promoter… More details

$310 / 0.05 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
MAZ, Polyclonal Antibody
Full Product Name
Phospho-MAZ (Thr72) Antibody
Product Gene Name
anti-MAZ antibody
Product Synonym Names
MAZ; MAZ_HUMAN; MAZI; MYC associated zinc finger protein; Myc-associated zinc finger protein; Pur-1; Pur1; Purine binding transcription factor; Purine-binding transcription factor; SAF 1; SAF 2; SAF-1; SAF-2; SAF-3; Serum amyloid A activating factor 1; Serum amyloid A activating factor 2; Transcription factor Zif87; ZF87; Zif87; Zinc finger protein 801; Zinc finger protein, 87 kilodaltons; ZNF801
Clonality
Polyclonal
Isotype
Rabbit IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Predicted Reactivity: Pig (100%)
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
Concentration
1mg/ml (lot specific)
Specificity
Phospho-MAZ (Thr72) Antibody detects endogenous levels of MAZ only when phosphorylated at Thr72.
Tissue Specificity: Present in kidney, liver and brain. In the brain, highest levels are found in motor cortex and midfrontal cortex (at protein level).
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
Antibody/Peptide Pairs
MAZ (Thr72) peptide (MBS9619245) is used for blocking the activity of MAZ (Thr72) antibody (MBS9614283)
Molecular Weight
48,608 Da
Chromosome Location
Chromosome: 16; NC_000016.9 (29817855..29822504). Location: 16p11.2
OMIM
600999
3D Structure
ModBase 3D Structure for P56270
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide derived from human MAZ around the phosphorylation site of Thr72.
Conjugation
Unconjugated
Fragment
Fab fragment
Subunit Structure
Interacts with BPTF.
Subcellular Location
Nucleus.
Note: In brains of Alzheimer disease patients, present in a plaque-like structures.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-MAZ antibody
Western Blot (WB), Peptide ELISA (EIA)
Application Notes for anti-MAZ antibody
WB: 1:1000-3000
Peptide ELISA: 1:20,000-1:40,000

Western Blot (WB) of anti-MAZ antibody

Western blot analysis of extracts from 293, using MAZ (Phospho-Thr72) Antibody.
Rabbit Anti-MAZ Polyclonal Antibody – Cat# MBS9614283

Western Blot (WB) of anti-MAZ antibody

Western blot analysis of MAZ (Phospho-Thr72) using PDGF treated NIH-3T3 whole cell lysates.
-/+ means absence or presence of N peptide（non-phospho peptide) and P peptide(phospho peptide).
Rabbit Anti-MAZ Polyclonal Antibody, Western Blot (WB) – Cat# MBS9614283

Other Notes

Small volumes of anti-MAZ antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MAZ purchase

MBS9614283 is an antibody targeting MAZ. Also known as Phospho-MAZ (Thr72) Antibody. Reactive in Human, Mouse, Rat
Predicted Reactivity: Pig (100%). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MAZ. It may not necessarily be applicable to this product.

NCBI GI #
110347459
NCBI GeneID
4150
NCBI Accession #
NP_001036004.1
UniProt Primary Accession #
P56270
UniProt Secondary Accession #
Q15703; Q8NFN7; Q99443; A8QJL9; G5E927
UniProt Related Accession #
P56270
GenBank Nucleotide #
NM_001042539.2
NCBI Official Full Name
myc-associated zinc finger protein isoform 2
NCBI Official Synonym Full Names
MYC-associated zinc finger protein (purine-binding transcription factor)
NCBI Official Symbol
MAZ
NCBI Official Synonym Symbols
PUR1; ZF87; Pur-1; SAF-1; SAF-2; SAF-3; Zif87; ZNF801
UniProt Protein Name
Myc-associated zinc finger protein
UniProt Synonym Protein Names
Pur-1; Purine-binding transcription factor; Serum amyloid A-activating factor-1; SAF-1; Transcription factor Zif87; ZF87; Zinc finger protein 801
Protein Family
Myc-associated zinc finger protein
UniProt Gene Name
MAZ
UniProt Synonym Gene Names
ZNF801; MAZI; SAF-1
UniProt Entry Name
MAZ_HUMAN
NCBI Protein Information
myc-associated zinc finger protein; MAZI; zinc finger protein 801; transcription factor Zif87; purine-binding transcription factor; serum amyloid A activating factor 1; serum amyloid A activating factor 2; serum amyloid A-activating factor-1; zinc-finger

UniProt Comments for MAZ

MAZ: a myc-associated zinc finger protein. An inflammation-responsive transcription factor with dual roles in transcription initiation and termination. Binds to two sites within the c-myc promoter. Also binds to multiple G/C-rich sites within the promoter of the SP1 family of transcription factors. Expressed in heart, brain, placenta, lung, liver, skeletal muscle and pancreas.

Protein type: C2H2-type zinc finger protein; RNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein binding; metal ion binding; chromatin binding

Biological Process: transcription initiation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; termination of RNA polymerase II transcription
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Research Articles on MAZ

1. these findings reveal that SAF-1 is a hitherto unrecognized participant in inducing VEGF expression in triple-negative breast cancer cells, an aggressive form of breast cancer that currently lacks effective treatment options.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MAZ antibody

 Reference Product  PubMed Publications
 DCC antibody  >2 publications with MAZ and DCC

Pathways associated with anti-MAZ antibody

 Products by Pathway  Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram

Diseases associated with anti-MAZ antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >35 publications with MAZ and Neoplasms
 Nervous System Diseases Antibodies  >14 publications with MAZ and Nervous System Diseases
 Pain Antibodies  >8 publications with MAZ and Pain
 Inflammation Antibodies  >7 publications with MAZ and Inflammation
 Breast Neoplasms Antibodies  >6 publications with MAZ and Breast Neoplasms
 Skin Diseases Antibodies  >6 publications with MAZ and Skin Diseases
 Necrosis Antibodies  >5 publications with MAZ and Necrosis
 Disease Models, Animal Antibodies  >4 publications with MAZ and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >3 publications with MAZ and Carcinoma, Hepatocellular
 Hyperplasia Antibodies  >2 publications with MAZ and Hyperplasia

Organs/Tissues associated with anti-MAZ antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >33 publications with MAZ and Blood
 Brain Antibodies  >24 publications with MAZ and Brain
 Bone Antibodies  >17 publications with MAZ and Bone
 Vascular Antibodies  >11 publications with MAZ and Vascular
 Muscle Antibodies  >10 publications with MAZ and Muscle
 Bone Marrow Antibodies  >9 publications with MAZ and Bone Marrow
 Liver Antibodies  >9 publications with MAZ and Liver
 Heart Antibodies  >9 publications with MAZ and Heart
 Nerve Antibodies  >8 publications with MAZ and Nerve
 Kidney Antibodies  >8 publications with MAZ and Kidney
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