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ADCY3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9603885

Mediates odorant detection (possibly) via modulation of intracellular cAMP concentration. More details

$325 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ADCY3, Polyclonal Antibody
Full Product Name
ADCY3 Antibody
Product Gene Name
anti-ADCY3 antibody
Product Synonym Names
AC-III; AC3; ADCY3; ADCY3_HUMAN; adenylate cyclase 3; Adenylate cyclase; Adenylate cyclase type 3; Adenylate cyclase type III; Adenylyl cyclase 3; ATP pyrophosphate lyase; ATP pyrophosphate-lyase 3; olfactive type
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Form/Format
Liquid;Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
Concentration
1mg/ml (lot specific)
Specificity
ADCY3 antibody detects endogenous levels of total ADCY3
Antibody/Peptide Pairs
ADCY3 peptide (MBS9622603) is used for blocking the activity of ADCY3 antibody (MBS9603885)
Molecular Weight
129 kDa
3D Structure
ModBase 3D Structure for O60266
Supply Chain Verification
Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available, please inquire.
Immunogen
A synthesized peptide derived from human ADCY3,corresponding to a region within C-terminal amino acids.
Similarity
The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal modules have no catalytic activity,but when they are brought together, enzyme activity is restored. The active site is at the inter face of the two modules.Belongs to the adenylyl cyclase class-4/guanylylcyclase family.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-ADCY3 antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-ADCY3 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
ELISA(peptide): 1:20000-1:40000

IMPORTANT: For western blots, incubate membrane with diluted antibody in 5% w/v milk , 1X TBS, 0.1% Tween®20 at 4°C with gentle shaking, overnight.

Western Blot (WB) of anti-ADCY3 antibody

Western blot analysis of ADCY3 expression in Rat olfactory epithelium lysate; Rat frontal cortex lysate, The lane on the left is treated with the antigen-specific peptide.
Rabbit Anti-ADCY3 Polyclonal Antibody – Cat# MBS9603885

Immunohistochemistry (IHC) of anti-ADCY3 antibody

MBS9603885 at 1/100 staining Mouse lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
Rabbit Anti-ADCY3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS9603885

Other Notes

Small volumes of anti-ADCY3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ADCY3 purchase

MBS9603885 is an antibody targeting ADCY3. Also known as ADCY3 Antibody. Reactive in Human,Mouse,Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ADCY3. It may not necessarily be applicable to this product.

NCBI GI #
1002341785
NCBI GeneID
109
NCBI Accession #
NP_001307542.1
UniProt Primary Accession #
O60266
UniProt Secondary Accession #
Q53T54; Q9UDB1; B3KT86
UniProt Related Accession #
O60266
GenBank Nucleotide #
NM_001320613.1
NCBI Official Full Name
adenylate cyclase type 3 isoform 1
NCBI Official Synonym Full Names
adenylate cyclase 3
NCBI Official Symbol
ADCY3
NCBI Official Synonym Symbols
AC3; AC-III; BMIQ19
UniProt Protein Name
Adenylate cyclase type 3
UniProt Synonym Protein Names
ATP pyrophosphate-lyase 3; Adenylate cyclase type III; AC-III; Adenylate cyclase, olfactive type; Adenylyl cyclase 3
Protein Family
Adenylate cyclase
UniProt Gene Name
ADCY3
UniProt Synonym Gene Names
KIAA0511; AC-III; AC3
NCBI Protein Information
adenylate cyclase type 3

NCBI Summary for ADCY3

This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
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UniProt Comments for ADCY3

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.
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Research Articles on ADCY3

1. This study showed that subjects carrying the G allele of the rs10182181 polymorphism may benefit more in terms of weight loss and improvement of body composition measurements when undertaking a hypocaloric low-fat diet as compared to a moderately-high-protein diet.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ADCY3 antibody

 Products by Pathway  Pathway Diagram
 Activation Of GABAB Receptors Pathway antibodies  Activation Of GABAB Receptors Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Adenylate Cyclase Activating Pathway antibodies  Adenylate Cyclase Activating Pathway Diagram
 Adenylate Cyclase Inhibitory Pathway antibodies  Adenylate Cyclase Inhibitory Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Aldosterone Synthesis And Secretion Pathway antibodies  Aldosterone Synthesis And Secretion Pathway Diagram
 Aldosterone Synthesis And Secretion Pathway antibodies  Aldosterone Synthesis And Secretion Pathway Diagram
 Aquaporin-mediated Transport Pathway antibodies  Aquaporin-mediated Transport Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram

Diseases associated with anti-ADCY3 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >4 publications with ADCY3 and Cardiovascular Diseases
 Depressive Disorder Antibodies  >3 publications with ADCY3 and Depressive Disorder
 Brain Diseases Antibodies  >3 publications with ADCY3 and Brain Diseases
 Disease Models, Animal Antibodies  >2 publications with ADCY3 and Disease Models, Animal
 Skin Diseases Antibodies  >1 publications with ADCY3 and Skin Diseases
 Atrophy Antibodies  >1 publications with ADCY3 and Atrophy
 Lung Diseases Antibodies  >1 publications with ADCY3 and Lung Diseases
 Nervous System Diseases Antibodies  >1 publications with ADCY3 and Nervous System Diseases
 Fatty Liver Antibodies  >1 publications with ADCY3 and Fatty Liver
 Immune System Diseases Antibodies  >1 publications with ADCY3 and Immune System Diseases

Organs/Tissues associated with anti-ADCY3 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with ADCY3 and Blood
 Connective Tissue Antibodies  >6 publications with ADCY3 and Connective Tissue
 Muscle Antibodies  >4 publications with ADCY3 and Muscle
 Heart Antibodies  >4 publications with ADCY3 and Heart
 Brain Antibodies  >4 publications with ADCY3 and Brain
 Liver Antibodies  >3 publications with ADCY3 and Liver
 Eye Antibodies  >2 publications with ADCY3 and Eye
 Kidney Antibodies  >2 publications with ADCY3 and Kidney
 Ovary Antibodies  >2 publications with ADCY3 and Ovary
 Bone Antibodies  >2 publications with ADCY3 and Bone
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