Cofilin (CFL1) Antibody – Rabbit Polyclonal

The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]

Cofilin-1: a cytoskeletal protein that controls actin depolymerization. Has a 5-10-fold higher affinity for ATP-actin monomers than cofilin-1. May promote filament assembly rather than disassembly. Two alternatively spliced variants are described. Isoform b is expressed predominantly in skeletal muscle and heart, while isoform a is expressed in various tissues.

Protein type: Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Cytoskeletal

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: actin cytoskeleton; cytoplasm; extracellular space; focal adhesion; membrane; nuclear matrix; nucleus; vesicle

Molecular Function: actin binding; protein binding

Biological Process: actin cytoskeleton organization and biogenesis; actin filament depolymerization; cytoskeleton organization and biogenesis; negative regulation of apoptosis; regulation of cell morphogenesis; response to virus; Rho protein signal transduction