MTMR7 Antibody – Rabbit Polyclonal

This gene encodes a member of the myotubularin family of tyrosine/dual-specificity phosphatases. The encoded protein is characterized by four distinct domains that are conserved among all members of the myotubularin family: the glucosyltransferase, Rab-like GTPase activator and myotubularins domain, the Rac-induced recruitment domain, the protein tyrosine phosphatases and dual-specificity phosphatases domain and the suppressor of variegation 3-9, enhancer-of-zeste, and trithorax interaction domain. This protein dephosphorylates the target substrates phosphatidylinositol 3-phosphate and inositol 1,3-bisphosphate. A pseudogene of this gene is found on chromosome 5. [provided by RefSeq, Mar 2009]

MTMR7: a protein of the myotubularin family. Myotubularins are a family of unique protein tyrosine phosphatases that utilize inositol phospholipids, rather than phosphoproteins, as physiological substrates. Myotubularins specifically dephosphorylate phosphatidylinositol 3-phosphate [PI(3)P] and phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2], generating phosphatidylinositol and phosphatidylinositol 5-phosphate [PI(5)P], respectively. PI(3)P and PI(3,5)P2 regulate membrane trafficking events through the recruitment of effector proteins containing the lipid-binding domains FYVE, PH, and ENTH. MTMR5, -9, -10, -11, -12, -13 are catalytically inactive lipid phosphatases but may mediate important protein-protein interactions. Expressed at high levels in the brain. Two alternatively spliced human isoforms have been described.

Protein type: EC 3.1.3.-; Protein phosphatase, tyrosine (non-receptor); Motility/polarity/chemotaxis; Phosphatase, lipid

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: membrane; cytosol

Molecular Function: protein tyrosine phosphatase activity

Biological Process: phospholipid metabolic process; inositol phosphate dephosphorylation; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation; protein amino acid dephosphorylation