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PTP22 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9512277

This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PTP22, Polyclonal Antibody
Full Product Name
PTP22 Rabbit Polyclonal Antibody
Product Gene Name
anti-PTP22 antibody
Product Synonym Gene Name
PTPN22
Product Synonym Names
PTPN22; PTPN8; Tyrosine-protein phosphatase non-receptor type 22; Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; Lymphoid phosphatase; LyP; PEST-domain phosphatase; PEP; BH6842; Tyrosine-protein phosphatase non-receptor type 22
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1mg/ml (lot specific)
Specificity
PTP22 Polyclonal Antibody detects endogenous levels of PTP22 protein.
Preparation and Storage
Store at -20 degree C/1 year
Molecular Weight
91,705 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (114356433..114414375, complement). Location: 1p13.2
OMIM
152700
3D Structure
ModBase 3D Structure for Q9Y2R2
Immunogen
Synthesized peptide derived from the N-terminal region of human PTP22.
Modification
Unmodified/Total
Applications Tested/Suitable for anti-PTP22 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-PTP22 antibody
WB: 1/500-1/2000
ELISA: 1/10000

Other Notes

Small volumes of anti-PTP22 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PTP22 purchase

MBS9512277 is an antibody targeting PTP22. Also known as PTP22 Rabbit Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PTP22. It may not necessarily be applicable to this product.

NCBI GI #
301171669
NCBI GeneID
26191
NCBI Accession #
NP_001180360.1
UniProt Primary Accession #
Q9Y2R2
UniProt Secondary Accession #
O95063; O95064; Q6IPX8; Q8WVM1; A0N0K6; B1ALC8; D4NZ71; E9PPI1
UniProt Related Accession #
Q9Y2R2
GenBank Nucleotide #
NM_001193431.1
NCBI Official Full Name
tyrosine-protein phosphatase non-receptor type 22 isoform 3
NCBI Official Synonym Full Names
protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
NCBI Official Symbol
PTPN22
NCBI Official Synonym Symbols
LYP; PEP; LYP1; LYP2; PTPN8
UniProt Protein Name
Tyrosine-protein phosphatase non-receptor type 22
UniProt Synonym Protein Names
Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP; Lymphoid phosphatase; LyP; PEST-domain phosphatase
UniProt Gene Name
PTPN22
UniProt Synonym Gene Names
PTPN8; LyP; PEP
UniProt Entry Name
PTN22_HUMAN
NCBI Protein Information
tyrosine-protein phosphatase non-receptor type 22; lymphoid phosphatase; PEST-domain phosphatase; lymphoid-specific protein tyrosine phosphatase; protein tyrosine phosphatase, non-receptor type 8; hematopoietic cell protein-tyrosine phosphatase 70Z-PEP

UniProt Comments for PTP22

PTPN22: Seems to act on Cbl. May play a role in regulating the function of Cbl and its associated protein kinases. Acts as negative regulator of T-cell receptor (TCR) signaling. Dephosphorylates and inactivates the SRC family kinases. Interacts with CSK. Interacts with LPXN. Predominantly expressed in lymphoid tissues and cells. Isoform 1 is expressed in thymocytes and both mature B and T-cells. Down-regulated by phosphorylation. Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Protein phosphatase, tyrosine (non-receptor); EC 3.1.3.48

Chromosomal Location of Human Ortholog: 1p13.2

Cellular Component: internal side of plasma membrane; perinuclear region of cytoplasm; cytoplasm; nucleus

Molecular Function: protein binding; protein tyrosine phosphatase activity; kinase binding; SH3 domain binding

Biological Process: regulation of B cell receptor signaling pathway; regulation of natural killer cell proliferation; negative regulation of T cell receptor signaling pathway; protein amino acid dephosphorylation; negative regulation of T cell activation; T cell differentiation; regulation of innate immune response

Disease: Diabetes Mellitus, Insulin-dependent; Systemic Lupus Erythematosus; Rheumatoid Arthritis
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Research Articles on PTP22

1. Knockdown of PTPN22 alters activation of inflammatory signal transducers, increasing secretion of T-helper 17-related inflammatory mediators.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PTP22 antibody

 Reference Product  PubMed Publications
 CSK antibody  >12 publications with PTP22 and CSK
 LCK antibody  >5 publications with PTP22 and LCK
 GRB2 antibody  >4 publications with PTP22 and GRB2
 CBL antibody  >2 publications with PTP22 and CBL
 ZAP70 antibody  >1 publications with PTP22 and ZAP70
 CD247 antibody  >1 publications with PTP22 and CD247

Diseases associated with anti-PTP22 antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >440 publications with PTP22 and Immune System Diseases
 Arthritis, Rheumatoid Antibodies  >256 publications with PTP22 and Arthritis, Rheumatoid
 Diabetes Mellitus, Type 1 Antibodies  >127 publications with PTP22 and Diabetes Mellitus, Type 1
 Lupus Erythematosus, Systemic Antibodies  >85 publications with PTP22 and Lupus Erythematosus, Systemic
 Inflammation Antibodies  >36 publications with PTP22 and Inflammation
 Inflammatory Bowel Diseases Antibodies  >24 publications with PTP22 and Inflammatory Bowel Diseases
 Necrosis Antibodies  >21 publications with PTP22 and Necrosis
 Vasculitis Antibodies  >16 publications with PTP22 and Vasculitis
 Lung Diseases Antibodies  >11 publications with PTP22 and Lung Diseases
 Neoplasms Antibodies  >11 publications with PTP22 and Neoplasms

Organs/Tissues associated with anti-PTP22 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >158 publications with PTP22 and Blood
 Thyroid Antibodies  >56 publications with PTP22 and Thyroid
 Skin Antibodies  >18 publications with PTP22 and Skin
 Pancreas Antibodies  >16 publications with PTP22 and Pancreas
 Thymus Antibodies  >11 publications with PTP22 and Thymus
 Bone Marrow Antibodies  >7 publications with PTP22 and Bone Marrow
 Connective Tissue Antibodies  >5 publications with PTP22 and Connective Tissue
 Muscle Antibodies  >4 publications with PTP22 and Muscle
 Lymph Node Antibodies  >3 publications with PTP22 and Lymph Node
 Brain Antibodies  >3 publications with PTP22 and Brain
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