Rabbit Anti-PTPRN Polyclonal Antibody – Cat# MBS9466048

Western blot analysis of extracts of various cell lines, using PTPRN at 1:1000 dilution.

PTPRN Antibody – Rabbit Polyclonal

Name: PTPRN Antibody; Polyclonal; Rabbit; Human/Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS9466048
Price: 320 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9466048

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic… More details

$320 / 0.05 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PTPRN, Polyclonal Antibody

Full Product Name

PTPRN Rabbit Polyclonal Antibody

Product Gene Name

anti-PTPRN antibody

Product Synonym Names

PTPRN; IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Form/Format

Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Purity/Purification

Affinity purification

Preparation and Storage

Store at -20 degree C. Avoid freeze/thaw cycles.

Molecular Weight

105,848 Da

Chromosome Location

Chromosome: 2; NC_000002.11 (220154345..220174295, complement). Location: 2q35-q36.1

OMIM

601773

3D Structure

ModBase 3D Structure for Q16849

Immunogen

Recombinant fusion protein of human PTPRN (NP_001186693.1).

Product Categories/Family for anti-PTPRN antibody

Primary Antibody

Applications Tested/Suitable for anti-PTPRN antibody

Western Blot (WB), Immunohistochemistry (IHC)

Application Notes for anti-PTPRN antibody

WB: 1:500-1:2000
IHC: 1:50-1:100

Other Notes

Small volumes of anti-PTPRN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PTPRN purchase

MBS9466048 is an antibody targeting PTPRN. Also known as PTPRN Rabbit Polyclonal Antibody. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PTPRN. It may not necessarily be applicable to this product.

NCBI GI #

47124459

NCBI GeneID

5798

NCBI Accession #

AAH70053.1

UniProt Primary Accession #

Q16849

UniProt Secondary Accession #

Q08319; Q53QD6; Q6NSL1; B4DK12; F5GZS3

UniProt Related Accession #

Q16849

NCBI Official Full Name

PTPRN protein

NCBI Official Synonym Full Names

protein tyrosine phosphatase, receptor type, N

NCBI Official Symbol

PTPRN

NCBI Official Synonym Symbols

IA2; IA-2; ICA512; R-PTP-N; IA-2/PTP

UniProt Protein Name

Receptor-type tyrosine-protein phosphatase-like N

UniProt Synonym Protein Names

Islet cell antigen 512; ICA 512; Islet cell autoantigen 3; PTP IA-2

Protein Family

Receptor-type tyrosine-protein phosphatase

UniProt Gene Name

PTPRN

UniProt Synonym Gene Names

ICA3; ICA512; R-PTP-N; ICA 512

UniProt Entry Name

PTPRN_HUMAN

NCBI Protein Information

receptor-type tyrosine-protein phosphatase-like N; ICA 512; PTP IA-2; islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N

UniProt Comments for PTPRN

PTPRN: Implicated in neuroendocrine secretory processes. May be involved in processes specific for neurosecretory granules, such as their biogenesis, trafficking or regulated exocytosis or may have a general role in neuroendocrine functions. Seems to lack intrinsic enzyme activity. May play a role in the regulation of secretory granules via its interaction with SNTB2. Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q35-q36.1

Cellular Component: integral to membrane

Molecular Function: GTPase binding; protein binding; spectrin binding; protein tyrosine phosphatase activity

Biological Process: response to reactive oxygen species; response to cAMP; response to estrogen stimulus; insulin secretion; cytokine and chemokine mediated signaling pathway; response to glucose stimulus; protein amino acid dephosphorylation; response to insulin stimulus

Research Articles on PTPRN

1. identification of cysteines that are critical for IA-2A binding of autoantibodies in patients with newly diagnosed type 1 diabetes

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PTPRN antibody

Reference Product	PubMed Publications
PTPRT antibody	>23 publications with PTPRN and PTPRT
INS antibody	>8 publications with PTPRN and INS
PTPRS antibody	>1 publications with PTPRN and PTPRS
MADD antibody	>1 publications with PTPRN and MADD
GAD2 antibody	>1 publications with PTPRN and GAD2

Pathways associated with anti-PTPRN antibody

Products by Pathway	Pathway Diagram
Type I Diabetes Mellitus Pathway antibodies	Type I Diabetes Mellitus Pathway Diagram
Type I Diabetes Mellitus Pathway antibodies	Type I Diabetes Mellitus Pathway Diagram

Diseases associated with anti-PTPRN antibody

Disease Name	Pubmed Publications
Autoimmune Diseases Antibodies	>189 publications with PTPRN and Autoimmune Diseases
Immune System Diseases Antibodies	>188 publications with PTPRN and Immune System Diseases
Neoplasms Antibodies	>14 publications with PTPRN and Neoplasms
Nervous System Diseases Antibodies	>9 publications with PTPRN and Nervous System Diseases
Disease Models, Animal Antibodies	>7 publications with PTPRN and Disease Models, Animal
Brain Diseases Antibodies	>4 publications with PTPRN and Brain Diseases
Kidney Diseases Antibodies	>3 publications with PTPRN and Kidney Diseases
Weight Loss Antibodies	>2 publications with PTPRN and Weight Loss
Inflammation Antibodies	>2 publications with PTPRN and Inflammation
Liver Diseases Antibodies	>2 publications with PTPRN and Liver Diseases

Organs/Tissues associated with anti-PTPRN antibody

Organ/Tissue Name	Pubmed Publications
Pancreas Antibodies	>130 publications with PTPRN and Pancreas
Brain Antibodies	>29 publications with PTPRN and Brain
Nerve Antibodies	>6 publications with PTPRN and Nerve
Lung Antibodies	>6 publications with PTPRN and Lung
Kidney Antibodies	>4 publications with PTPRN and Kidney
Pituitary Gland Antibodies	>4 publications with PTPRN and Pituitary Gland
Muscle Antibodies	>3 publications with PTPRN and Muscle
Eye Antibodies	>3 publications with PTPRN and Eye
Embryonic Tissue Antibodies	>2 publications with PTPRN and Embryonic Tissue