AURKA Antibody – Rabbit Polyclonal

AurA: a member of the AUR family of kinases. A cell cycle-regulated serine/threonine protein kinase that is overexpressed in many tumor cell lines. Regulated by phosphorylation-dependent proteasomal degradation. Localized to mitotic centrosomes and spindle microtubules and is required for centrosome maturation. Loss of Aurora A leads to defective mitotic spindles and gross errors in chromosome segregation. Required for centrosome duplication and chromosome segregation. Overexpression in culture drives transformation and aneuploidy, and negatively regulates p53. Amplified or overexpressed in many tumors or cell lines. Found as a skin tumor susceptibility gene in mouse, and a human SNP in a degradation domain is weakly cancer-associated and undergoes allele-specific amplification. Inhibitors: VX-680, ZM447439, Hesperadin, SNS-595.

Protein type: Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; EC 2.7.11.1; Other group; AUR family

Cellular Component: germinal vesicle; centrosome; microtubule; pronucleus; spindle pole centrosome; axon hillock; microtubule cytoskeleton; cytoskeleton; spindle microtubule; perinuclear region of cytoplasm; cytoplasm; microtubule organizing center; spindle; spindle midzone; nucleus; condensed nuclear chromosome, pericentric region

Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; ubiquitin protein ligase binding; transferase activity, transferring phosphorus-containing groups; protein serine/threonine/tyrosine kinase activity; nucleotide binding; histone serine kinase activity; kinase activity; protein kinase binding; ATP binding; protein kinase activity

Biological Process: spindle stabilization; meiosis; mitosis; regulation of protein stability; microtubule cytoskeleton organization and biogenesis; cell cycle; regulation of cytokinesis; protein amino acid phosphorylation; mitotic centrosome separation; mitotic spindle organization and biogenesis; cell projection organization and biogenesis; centrosome localization; cell division; centrosome organization and biogenesis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; mitotic cell cycle; negative regulation of protein binding; phosphorylation; spindle assembly involved in female meiosis I; meiotic spindle organization and biogenesis; negative regulation of apoptosis; anterior/posterior axis specification