NPR1 Antibody – Rabbit Polyclonal

ANPA: natriuretic peptide receptor A, which mediates natriuretic, diuretic, and vasorelaxing actions of the natriuretic peptides. Contains five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. Has guanylate cyclase activity on binding of ANF. Hypertensive SHR Rat has polymorphism at the locus. Human non-coding polymorphisms can alter expression up to two-fold, and have been associated with hypertension. A coding SNP is associated with hypertension and myocardial infarction.

Protein type: EC 4.6.1.2; Guanylyl cyclase; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); RGC family; RGC group; Receptor, misc.

Chromosomal Location of Human Ortholog: 3 F1|3 39.23 cM

Cellular Component: guanylate cyclase complex, soluble; plasma membrane; receptor complex

Molecular Function: GTP binding; guanylate cyclase activity; hormone binding; natriuretic peptide receptor activity; peptide hormone binding; protein kinase binding

Biological Process: cell surface receptor linked signal transduction; cGMP biosynthetic process; dopamine metabolic process; negative regulation of smooth muscle cell proliferation; positive regulation of cGMP biosynthetic process; receptor guanylyl cyclase signaling pathway; regulation of blood pressure