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C5A Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6460698

C5a is a protein fragment released from complement component C5. This gene is mapped to 9q33.2. The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is… More details

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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
C5a, Polyclonal Antibody
Full Product Name
C5a, NT (Anaphylatoxin C5a Analog, Anaphylatoxin C5a, C5, C5a, Complement C5, Complement Component C5, Complement Component C5a, CPAMD 4, CPAMD4) (HRP)
Product Gene Name
anti-C5a antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Rat
Form/Format
Supplied as a liquid in PBS, pH 7.2. Labeled with Horseradish Peroxidase (HRP).
Purity/Purification
Purified by Immunoaffinity chromatography.
Specificity
Recognizes rat C5a.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months after receipt at -20 degree C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
8,981 Da
3D Structure
ModBase 3D Structure for P08650
Immunogen
Synthetic peptide corresponding to aa59-77, TIADKIRKESHHKGMLLGR at the C-terminal, of rat C5a. The sequence is different in mouse by five amino acids.
Conjugate
HRP
Note
Preservative Free

Product Categories/Family for anti-C5a antibody

Antibodies; Complement
Applications Tested/Suitable for anti-C5a antibody
Western Blot (WB)
Application Notes for anti-C5a antibody
Applications are based on unconjugated antibody.

Testing Data of anti-C5a antibody

All lanes: 303165 at 0.5ug/ml Lane 1: Rat Liver Tissue Lysate at 40ug Lane 2: Mouse Liver Tissue Lysate at 40ug Lane 3: NIH Whole Cell Lysate at 40ug Lane 4: HEPA Whole Cell Lysate at 40ug Lane 5: PC12 Whole Cell Lysate at 40ug Predicted band size: 115kD Observed band size: 115kD
Rabbit Anti-C5A Polyclonal Antibody – Cat# MBS6460698

Testing Data of anti-C5a antibody

Rabbit Anti-C5A Polyclonal Antibody, Testing Data – Cat# MBS6460698

Product References and Citations for anti-C5a antibody

1. Delgado-Cervino, E., Fontan, G., Lopez-Trascara, M. C5 complement deficiency in a Spanish family: molecular characterization of the double mutation responsible for the defect. Molec. Immun. 42: 105-111, 2005. 2. Pfarr, N., Prawitt, D., Kirschfink, M., Schroff, C., Knuf, M., Habermehl, P., Mannhardt, W., Zepp, F., Fairbrother, W. G., Loos, M., Burge, C. B., Pohlenz, J. Linking C5 deficiency to an exonic splicer enhancer mutation. J. Immun. 174: 4172-4177, 2005. Note: Erratum: J. Immun. 182: 5152 only, 2009.

Other Notes

Small volumes of anti-C5a antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for C5a purchase

MBS6460698 is an antibody targeting C5a. Also known as C5a, NT (Anaphylatoxin C5a Analog, Anaphylatoxin C5a, C5, C5a, Complement C5, Complement Component C5, Complement Component C5a, CPAMD 4, CPAMD4) (HRP). Reactive in Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for C5a. It may not necessarily be applicable to this product.

NCBI GI #
46397770
NCBI GeneID
362119
NCBI Accession #
P08650.2
UniProt Primary Accession #
P08650
UniProt Secondary Accession #
Q63078
UniProt Related Accession #
P08650
NCBI Official Full Name
Complement C5
NCBI Official Synonym Full Names
complement component 5
NCBI Official Symbol
C5
NCBI Official Synonym Symbols
Hc; C5a; RGD1561905
UniProt Protein Name
Complement C5
Protein Family
C5a anaphylatoxin chemotactic receptor
UniProt Gene Name
C5
UniProt Entry Name
CO5_RAT
NCBI Protein Information
complement C5; anaphylatoxin

NCBI Summary for C5a

likely component of the classical pathway of the complement cascade; may be involved with tissue injury associated with ischemia or sepsis; may be a component of the membrane attack complex [RGD, Feb 2006]

UniProt Comments for C5a

C5: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Defects in C5 are the cause of complement component 5 deficiency (C5D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705).

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular space

Molecular Function: C5a anaphylatoxin chemotactic receptor binding

Biological Process: cellular calcium ion homeostasis; positive regulation of angiogenesis; positive regulation of chemotaxis; in utero embryonic development; complement activation, alternative pathway; glucose homeostasis; chemotaxis; inflammatory response; negative regulation of dopamine secretion; complement activation, classical pathway; leukocyte migration during inflammatory response
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Research Articles on C5a

1. data indicate that the mechanism of IL-6 and TGF-beta1 production in renal tissue of Thy-1N rats is associated with sublytic C5b-9 up-regulated p300 and p300-mediated C/EBPbeta acetylation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-C5a antibody

 Products by Pathway  Pathway Diagram
 Activation Of C3 And C5 Pathway antibodies  Activation Of C3 And C5 Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Complement Activation, Classical Pathway antibodies  Complement Activation, Classical Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram

Organs/Tissues associated with anti-C5a antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >461 publications with C5a and Kidney
 Liver Antibodies  >432 publications with C5a and Liver
 Embryonic Tissue Antibodies  >63 publications with C5a and Embryonic Tissue
 Adrenal Gland Antibodies  >10 publications with C5a and Adrenal Gland
 Uncharacterized Tissue Antibodies  >2 publications with C5a and Uncharacterized Tissue
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