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Tenascin C (TNC) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2001726
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MBS2001726 is an antibody targeting TNC. Also known as Polyclonal Antibody to Tenascin C (TNC). Reactive in Rat. Host: Rabbit. More details

$215 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Tenascin C (TNC), Polyclonal Antibody
Full Product Name
Polyclonal Antibody to Tenascin C (TNC)
Product Gene Name
anti-TNC antibody
Immunogen Sequence
Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF- DGQCICED GFTGSDCAEL SCPGDCHGHG RCVNGQCICH EGFTGXDCKE QRCPSDCHGQ GRCEDGQCIC HEGFTGLDCG QRSCPNDCSN QGQCVAGRCI CNEGYTGVDC S
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Rat
Form/Format
Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
Purity/Purification
Affinity Chromatography
Concentration
0.21mg/ml (lot specific)
Specificity
The antibody is a rabbit polyclonal antibody raised against TNC. It has been selected for its ability to recognize TNC in immunohistochemical staining andwestern blotting.
Preparation and Storage
Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
Matching Pairs
Unconjugated Antibody: TNC (MBS2001726)
Biotin Conjugated Antibody: TNC (MBS2002016)
Matching Pairs
Unconjugated Antibody: TNC (MBS2001726)
Immunogen: TNC (MBS2012158)
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Molecular Weight
221,756 Da
3D Structure
ModBase 3D Structure for B2LYI9
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Immunogen
Recombinant TNC (Asp513~Ser621) expressed in E.coli.
Cross Reactivity
Rat
Conjugated Antibody
The APC conjugated antibody version of this item is also available as catalog #MBS2061407
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for anti-TNC antibody
Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)
Application Notes for anti-TNC antibody
Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200

Western Blot (WB) of anti-TNC antibody

Western Blot: Sample: Rat Placenta lysate; Primary Ab: 1.5ug/ml Rabbit Anti-Rat TNC Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
Rabbit Anti-TNC Polyclonal Antibody – Cat# MBS2001726

Western Blot (WB) of anti-TNC antibody

Western Blot: Sample: Recombinant protein.
Rabbit Anti-TNC Polyclonal Antibody, Western Blot (WB) – Cat# MBS2001726

Immunohistochemistry (IHC) of anti-TNC antibody

DAB staining on IHC-P. Samples: Rat Tissue)
Rabbit Anti-TNC Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS2001726

Other Notes

Small volumes of anti-TNC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TNC. It may not necessarily be applicable to this product.

NCBI GI #
198278535
NCBI GeneID
116640
NCBI Accession #
NP_446313.1
UniProt Primary Accession #
B2LYI9
GenBank Nucleotide #
NM_053861.1
NCBI Official Full Name
tenascin
NCBI Official Synonym Full Names
tenascin C
NCBI Official Symbol
Tnc
UniProt Protein Name
Tenascin C
UniProt Synonym Protein Names
Tenascin C
Protein Family
Tenascin
UniProt Gene Name
Tnc
NCBI Protein Information
tenascin

NCBI Summary for TNC

extracellular matrix glycoprotein; inhibits the attachment of fibroblasts to adhesive proteins [RGD, Feb 2006]

UniProt Comments for TNC

TNC: Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. Belongs to the tenascin family. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q24

Cellular Component: basement membrane; extracellular matrix; extracellular region; extracellular space; focal adhesion; membrane; proteinaceous extracellular matrix

Molecular Function: syndecan binding

Biological Process: axon regeneration in the peripheral nervous system; cell adhesion; negative regulation of cell adhesion; neuromuscular junction development; neuron projection development; odontogenesis of dentine-containing teeth; osteoblast differentiation; positive regulation of cell proliferation; response to ethanol; response to mechanical stimulus; response to wounding; wound healing
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Research Articles on TNC

1. Epicardium-derived cells (EPDCs) from post-myocardial infarction hearts highly expressed tenascin-C, which induces pro-IL-1beta transcription in EPDCs and thus contributes to inflammasome activation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TNC antibody

 Reference Product  PubMed Publications
 Itgav antibody  >1 publications with TNC and Itgav
 Ptk2 antibody  >1 publications with TNC and Ptk2
 Itgb1 antibody  >1 publications with TNC and Itgb1
 Sdc4 antibody  >1 publications with TNC and Sdc4

Pathways associated with anti-TNC antibody

 Products by Pathway  Pathway Diagram
 Cardiovascular Signaling Pathway antibodies  Cardiovascular Signaling Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 MicroRNAs In Cancer Pathway antibodies  MicroRNAs In Cancer Pathway Diagram

Diseases associated with anti-TNC antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >114 publications with TNC and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >108 publications with TNC and Nervous System Diseases
 Heart Diseases Antibodies  >82 publications with TNC and Heart Diseases
 Disease Models, Animal Antibodies  >68 publications with TNC and Disease Models, Animal
 Brain Diseases Antibodies  >64 publications with TNC and Brain Diseases
 Inflammation Antibodies  >59 publications with TNC and Inflammation
 Lung Diseases Antibodies  >31 publications with TNC and Lung Diseases
 Necrosis Antibodies  >28 publications with TNC and Necrosis
 Breast Neoplasms Antibodies  >26 publications with TNC and Breast Neoplasms
 Fibrosis Antibodies  >25 publications with TNC and Fibrosis

Organs/Tissues associated with anti-TNC antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >631 publications with TNC and Muscle
 Brain Antibodies  >145 publications with TNC and Brain
 Thymus Antibodies  >82 publications with TNC and Thymus
 Embryonic Tissue Antibodies  >54 publications with TNC and Embryonic Tissue
 Lung Antibodies  >54 publications with TNC and Lung
 Connective Tissue Antibodies  >25 publications with TNC and Connective Tissue
 Kidney Antibodies  >16 publications with TNC and Kidney
 Eye Antibodies  >15 publications with TNC and Eye
 Colon Antibodies  >12 publications with TNC and Colon
 Adipose Tissue Antibodies  >11 publications with TNC and Adipose Tissue
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