EAAT1 Positive Control

SLC1A3: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter, SLC family; Transporter

Cellular Component: basolateral plasma membrane; cell projection; cell soma; cell surface; dendritic spine; fibril; integral to membrane; membrane; mitochondrial inner membrane; neuron projection; plasma membrane; synapse

Molecular Function: amino acid binding; glutamate binding; high-affinity glutamate transmembrane transporter activity; L-glutamate transmembrane transporter activity; protein binding; sodium:dicarboxylate symporter activity; symporter activity

Biological Process: auditory behavior; cranial nerve development; dicarboxylic acid transport; gamma-aminobutyric acid biosynthetic process; glutamate biosynthetic process; glutamate metabolic process; L-glutamate import; L-glutamate transport; malate-aspartate shuttle; neuromuscular process controlling balance; neuron morphogenesis during differentiation; positive regulation of defense response to virus by host; positive regulation of synaptic transmission; response to amino acid stimulus; response to antibiotic; response to drug; response to inorganic substance; response to light stimulus; response to wounding; sensory perception of sound; transport