ASIC1 Human Protein

Function: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca2+, Li+ and K+. Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca2+ entry into neurons upon acidosis. This Ca2+ overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca2+ concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear

By similarity.

Subunit structure: Homotrimer or heterotrimer with other ASIC proteins

By similarity. Interacts with STOM and ASIC2

By similarity. Interacts with PRKCABP. Ref.8 Ref.10

Subcellular location: Cell membrane; Multi-pass membrane protein

By similarity. Note: Localizes in synaptosomes at dendritic synapses of neurons. Colocalizes with DLG4

By similarity. Ref.10

Tissue specificity: Expressed in most or all neurons.

Post-translational modification: Phosphorylation by PKA regulates interaction with PRKCABP and subcellular location. Phosphorylation by PKC may regulate the channel.

Miscellaneous: Potentiated by Ca2+, Mg2+, Ba2+ and multivalent cations. Inhibited by anti-inflammatory drugs like salicylic acid

By similarity. Potentiated by FMRFamide-related neuropeptides. PH dependence may be regulated by serine proteases.

Sequence similarities: Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. ASIC1 subfamily. [View classification]