P2RX4 Human Protein

P2X4: Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin. Belongs to the P2X receptor family.

Protein type: Membrane protein, multi-pass; Channel, ligand-gated; Membrane protein, integral

Chromosomal Location of Human Ortholog: 12q24.32

Cellular Component: membrane; cell soma; perinuclear region of cytoplasm; apical part of cell; lysosomal membrane; integral to plasma membrane; postsynaptic density; dendritic spine; plasma membrane; terminal button; integral to nuclear inner membrane; cell junction

Molecular Function: protein homodimerization activity; copper ion binding; zinc ion binding; cadherin binding; drug binding; ATP binding; purinergic nucleotide receptor activity; ATP-gated cation channel activity; receptor binding

Biological Process: positive regulation of nitric oxide biosynthetic process; generation of action potential; positive regulation of calcium-mediated signaling; regulation of sodium ion transport; sensory perception of pain; signal transduction; vasodilation; response to ATP; endothelial cell activation; membrane depolarization; transport; calcium ion transport; regulation of blood pressure; positive regulation of prostaglandin secretion; tissue homeostasis; regulation of excitatory postsynaptic membrane potential; positive regulation of calcium ion transport; nitric oxide biosynthetic process; protein homooligomerization