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COMP siRNA – Cartilage Oligomeric Matrix Protein (Rat)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS829857

MBS829857 is an siRNA targeting COMP. Also known as COMP siRNA (Rat). Reactive in Rat. Host: Synthetic. siRNA to inhibit COMP expression using RNA interference More details

$480 / 15 nmol +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
COMP, siRNA
Full Product Name
COMP siRNA (Rat)
Product Gene Name
COMP sirna
Product Synonym Names
Cartilage oligomeric matrix protein; COMP
Host
Synthetic
Species Reactivity
Rat
Form/Format
Lyophilized powder
Purity/Purification
> 97%
Specificity
COMP siRNA (Rat) is a target-specific 19-23 nt siRNA oligo duplexes designed to knock down gene expression.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Molecular Weight
82,664 Da
3D Structure
ModBase 3D Structure for P35444
Negative Control
siRNA Negative Control (Catalog# MBS8241404) is a non-targeting 21 nt siRNA recommended as a negative control for experiments using targeted siRNA transfection.
Quality Control
Oligonucleotide synthesis is monitored base by base through trityl analysis to ensure appropriate coupling efficiency. The oligo is subsequently purified by affinity-solid phase extraction. The annealed RNA duplex is further analyzed by mass spectrometry to verify the exact composition of the duplex. Each lot is compared to the previous lot by mass spectrometry to ensure maximum lot-to-lot consistency.
Directions for Use
We recommends transfection with 100 nM siRNA 48 to 72 hours prior to cell lysis. Before resuspending, briefly centrifuge the tube to ensure the lyophilized siRNA is at the bottom of the tube. Resuspend the siRNA oligos to an appropriate concentration with DEPC water. For each vial, suitable for 250 transfections in 24 well plate (20 pmol for each well).
Components
We offer pre-designed sets of 3 different target-specific siRNA oligo duplexes of rat COMP gene. Each vial contains 5 nmol of lyophilized siRNA. The duplexes can be transfected individually or pooled together to achieve knockdown of the target gene, which is most commonly assessed by qPCR or western blot. Our siRNA oligos are also chemically modified (2'-OMe) at no extra charge for increased stability and enhanced knockdown in vitro and in vivo.
Applications Tested/Suitable for COMP sirna
RNA Interference (RNAi)

Other Notes

Small volumes of COMP sirna vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for COMP. It may not necessarily be applicable to this product.

NCBI GI #
6978679
NCBI GeneID
25304
NCBI Accession #
NP_036966.1
UniProt Primary Accession #
P35444
UniProt Related Accession #
P35444
GenBank Nucleotide #
NM_012834.1
NCBI Official Full Name
cartilage oligomeric matrix protein
NCBI Official Synonym Full Names
cartilage oligomeric matrix protein
NCBI Official Symbol
Comp
UniProt Protein Name
Cartilage oligomeric matrix protein
Protein Family
Cartilage oligomeric matrix protein
UniProt Gene Name
Comp
UniProt Synonym Gene Names
COMP
UniProt Entry Name
COMP_RAT
NCBI Protein Information
cartilage oligomeric matrix protein

NCBI Summary for COMP

extracellular matrix protein that interacts with fibronectin and may play a role in extracellular matrix assembly and molecular interactions [RGD, Feb 2006]

UniProt Comments for COMP

May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP) (). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7.
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Research Articles on COMP

1. COMP-Ang1-stimulated proliferation, differentiation, and migration of progenitor cells may involve the Tie-2-mediated activation of p38 MAPK and PI3K/Akt pathways

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with COMP sirna

 Reference Product  PubMed Publications
 Cd36 sirna  >45 publications with COMP and Cd36
 Itga2b sirna  >2 publications with COMP and Itga2b
 Itga7 sirna  >2 publications with COMP and Itga7
 Cd47 sirna  >2 publications with COMP and Cd47
 Itgav sirna  >1 publications with COMP and Itgav

Pathways associated with COMP sirna

 Products by Pathway  Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 Malaria Pathway antibodies  Malaria Pathway Diagram
 PI3K-Akt Signaling Pathway antibodies  PI3K-Akt Signaling Pathway Diagram

Diseases associated with COMP sirna

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1239 publications with COMP and Inflammation
 Necrosis Antibodies  >1071 publications with COMP and Necrosis
 Immune System Diseases Antibodies  >997 publications with COMP and Immune System Diseases
 Liver Diseases Antibodies  >910 publications with COMP and Liver Diseases
 Kidney Diseases Antibodies  >722 publications with COMP and Kidney Diseases
 Hypertension Antibodies  >691 publications with COMP and Hypertension
 Fatty Liver Antibodies  >631 publications with COMP and Fatty Liver
 Weight Loss Antibodies  >582 publications with COMP and Weight Loss
 Weight Gain Antibodies  >526 publications with COMP and Weight Gain
 Atrophy Antibodies  >438 publications with COMP and Atrophy

Organs/Tissues associated with COMP sirna

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >22433 publications with COMP and Brain
 Muscle Antibodies  >8343 publications with COMP and Muscle
 Connective Tissue Antibodies  >1840 publications with COMP and Connective Tissue
 Testis Antibodies  >1798 publications with COMP and Testis
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