KDR siRNA – Vascular Endothelial Growth Factor Receptor 2 (Rat)

VEGFR2: a receptor tyrosine kinase of the VEGFR family. High affinity receptor for VEGF and VEGF-C. Ligand binding induces autophosphorylation and activation. Activated receptor recruits proteins including Shc, GRB2, PI3K, Nck, SHP-1 and SHP-2. Plays a key role in vascular development and regulation of vascular permeability.

Protein type: Kinase, protein; Protein kinase, tyrosine (receptor); Protein kinase, TK; EC 2.7.10.1; Membrane protein, integral; TK group; VEGFR family

Cellular Component: Golgi apparatus; neuron projection; cell surface; endoplasmic reticulum; integral to plasma membrane; early endosome; cytoplasmic membrane-bound vesicle; lipid raft; cell soma; cytoplasm; plasma membrane; nucleus; cell junction; endosome; external side of plasma membrane

Molecular Function: integrin binding; vascular endothelial growth factor receptor activity; protein binding; growth factor binding; protein-tyrosine kinase activity; ATP binding

Biological Process: positive regulation of positive chemotaxis; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; cell maturation; positive regulation of calcium-mediated signaling; positive regulation of vasodilation; positive regulation of long-term neuronal synaptic plasticity; calcium ion homeostasis; regulation of cell shape; elevation of cytosolic calcium ion concentration; positive regulation of focal adhesion formation; positive regulation of MAPKKK cascade; ovarian follicle development; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; hemopoiesis; negative regulation of neuron apoptosis; angiogenesis; vasculogenesis; positive regulation of TOR signaling pathway; positive regulation of BMP signaling pathway; aging; response to drug; endothelial cell differentiation; positive regulation of neurogenesis; cell migration; cell fate commitment; embryonic hemopoiesis; male gonad development; regulation of endothelial cell differentiation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of angiogenesis; branching morphogenesis of a tube; cell migration during sprouting angiogenesis; response to hypoxia; positive regulation of endothelial cell proliferation; positive regulation of protein amino acid phosphorylation; vascular endothelial growth factor receptor signaling pathway; lymph vessel development; hyaluronan metabolic process; surfactant homeostasis; alveolus development; positive regulation of epithelial cell proliferation; neurite morphogenesis; lung development; positive regulation of cell migration; negative regulation of apoptosis; positive regulation of nitric-oxide synthase biosynthetic process