MYOD1 siRNA – Myoblast Determination Protein 1 (Rat)

MyoD: a transcription factor of the basic helix-loop-helix family and the myogenic factors subfamily. Involved in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. It is involved in muscle cell differentiation, and is essential for repair of damaged tissue. It activates its own transcription which may stabilize commitment to myogenesis.

Protein type: Transcription factor; DNA-binding; RNA splicing

Cellular Component: nucleoplasm; transcription factor complex; myofibril; cytoplasm; nuclear chromatin; nucleus

Molecular Function: protein dimerization activity; RNA polymerase II transcription factor activity, enhancer binding; enzyme binding; DNA binding; sequence-specific DNA binding; chromatin DNA binding; protein heterodimerization activity; ubiquitin protein ligase binding; chromatin binding; transcription factor binding; transcription factor activity; nuclear hormone receptor binding

Biological Process: transcription from RNA polymerase II promoter; muscle development; skeletal muscle fiber adaptation; regulation of RNA splicing; myotube differentiation involved in skeletal muscle regeneration; positive regulation of transcription, DNA-dependent; skeletal muscle fiber development; skeletal muscle atrophy; positive regulation of skeletal muscle fiber development; myoblast cell fate determination; myoblast fusion; skeletal muscle development; transcription, DNA-dependent; positive regulation of skeletal muscle regeneration; myotube differentiation; skeletal muscle regeneration; myotube cell development; cellular response to starvation; positive regulation of myoblast differentiation; myoblast differentiation; regulation of transcription from RNA polymerase II promoter; positive regulation of muscle cell differentiation; striated muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of alternative nuclear mRNA splicing, via spliceosome