RAC1 siRNA – Ras-Related C3 Botulinum Toxin Substrate 1 (Rat)

RAC1: a plasma membrane-associated member of the Rho-GTPase family. Plays a key role in cytoskeletal reorganization, membrane trafficking, transcriptional regulation and cell growth and development. GTP binding stimulates its activity. Phosphorylation by Akt may inhibit GTP binding of Rac1, therefore attenuating the downstream signal transduction pathway. Found in a trimeric complex composed of DOCK1 and ELMO1, which plays a central role in phagocytosis of apoptotic cells. Two alternatively spliced isoforms have been described.

Protein type: G protein, monomeric; Motility/polarity/chemotaxis; G protein; G protein, monomeric, Rho

Cellular Component: extrinsic to plasma membrane; focal adhesion; cytoplasmic membrane-bound vesicle; actin filament; trans-Golgi network; cytosol; Golgi membrane; cell projection; membrane; lamellipodium; cytoplasm; melanosome; cytoplasmic vesicle; phagocytic cup

Molecular Function: GTPase activity; protein binding; enzyme binding; GTP binding; GTP-dependent protein binding; Rho GDP-dissociation inhibitor binding; thioesterase binding; histone deacetylase binding; protein kinase binding; Rab GTPase binding

Biological Process: axon guidance; metabolic process; cell motility involved in cell locomotion; Rac protein signal transduction; regulation of neuron maturation; chemotaxis; regulation of cell migration; localization within membrane; positive regulation of focal adhesion formation; actin filament polymerization; small GTPase mediated signal transduction; positive regulation of stress fiber formation; dendrite development; regulation of cell morphogenesis; cell adhesion; bone resorption; lamellipodium biogenesis; embryonic olfactory bulb interneuron precursor migration; intercellular junction assembly and maintenance; cell migration; mast cell chemotaxis; Wnt receptor signaling pathway, planar cell polarity pathway; dendrite morphogenesis; synaptic transmission, GABAergic; positive regulation of phosphoinositide 3-kinase activity; actin filament organization; endocytosis; engulfment of apoptotic cell; cerebral cortex GABAergic interneuron development; cytoskeleton organization and biogenesis; cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of interleukin-23 production; hyperosmotic response; positive regulation of actin filament polymerization; homeostasis of number of cells within a tissue; organization of an anatomical structure; auditory receptor cell morphogenesis; ruffle organization and biogenesis; cerebral cortex radially oriented cell migration; positive regulation of protein amino acid phosphorylation; phagocytosis, engulfment; actin cytoskeleton organization and biogenesis; positive regulation of DNA replication