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ACVRL1 Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1578711

MBS1578711 is a recombinant protein targeting ACVRL1. Also known as Recombinant Mouse ACVRL1 Protein, N-SUMO & C-His. Host: E coli. More details

$435 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ACVRL1, Recombinant Protein
Full Product Name
Recombinant Mouse ACVRL1 Protein, N-SUMO & C-His
Product Gene Name
ACVRL1 recombinant protein
Product Synonym Names
Serine/threonine-protein kinase receptor R3; SKR3; 2.7.11.30; Activin receptor-like kinase 1; ALK-1; TGF-B superfamily receptor type I; TSR-I; Acvrl1; Acvrlk1; Alk-1
Host
E coli
Form/Format
Lyophilized from a solution in PBS pH7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Purity/Purification
>90% as determined by SDS-PAGE
Preparation and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 degree C for one week. Store at -20 degree C for twelve months from the date of receipt.
Molecular Weight
56,519 Da
Sequence Positions
Asp23-Pro119
3D Structure
ModBase 3D Structure for Q61288
Species
Mouse
Reconstitution
Reconstitute in sterile water for a stock solution.

Product Categories/Family for ACVRL1 recombinant protein

Recombinant Proteins
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for ACVRL1 recombinant protein
SDS-PAGE (SDS), Western Blot (WB), ELISA (EIA), Immunogen

Other Notes

Small volumes of ACVRL1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ACVRL1. It may not necessarily be applicable to this product.

NCBI GI #
471015970
NCBI GeneID
11482
NCBI Accession #
NP_001264186.1
UniProt Primary Accession #
Q61288
UniProt Secondary Accession #
Q61289; Q91YR0
UniProt Related Accession #
Q61288
GenBank Nucleotide #
NM_001277257.1
NCBI Official Full Name
serine/threonine-protein kinase receptor R3 isoform a
NCBI Official Synonym Full Names
activin A receptor, type II-like 1
NCBI Official Symbol
Acvrl1
NCBI Official Synonym Symbols
Alk1; Acvrlk1; AI115505; AI427544
UniProt Protein Name
Serine/threonine-protein kinase receptor R3
UniProt Synonym Protein Names
Activin receptor-like kinase 1; ALK-1; TGF-B superfamily receptor type I; TSR-I
Protein Family
Serine/threonine-protein kinase receptor
UniProt Gene Name
Acvrl1
UniProt Synonym Gene Names
Acvrlk1; Alk-1; SKR3; ALK-1; TSR-I
UniProt Entry Name
ACVL1_MOUSE
NCBI Protein Information
serine/threonine-protein kinase receptor R3

UniProt Comments for ACVRL1

ALK1: a kinase of the STKR family. A type I cell-surface receptor for the TGF-beta superfamily of ligands including Activin A. Highly expressed in human placenta and lung. Deficiency causes hemorrhagic telangiectasia type 2 also known as Rendu-Osler-Weber syndrome 2.

Protein type: EC 2.7.11.30; Protein kinase, TKL; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Kinase, protein; TKL group; STKR family; Type1 subfamily

Cellular Component: cell soma; cell surface; dendrite; integral to plasma membrane; plasma membrane

Molecular Function: activin binding; activin receptor activity, type I; ATP binding; protein binding; protein kinase binding; protein serine/threonine kinase activity; receptor signaling protein serine/threonine kinase activity; SMAD binding; transforming growth factor beta binding; transforming growth factor beta receptor activity; transforming growth factor beta receptor activity, type I

Biological Process: angiogenesis; blood circulation; blood vessel morphogenesis; blood vessel remodeling; BMP signaling pathway; endothelial cell activation; in utero embryonic development; lymphangiogenesis; negative regulation of blood vessel endothelial cell migration; negative regulation of cell adhesion; negative regulation of cell growth; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of endothelial cell differentiation; negative regulation of endothelial cell proliferation; negative regulation of focal adhesion formation; positive regulation of angiogenesis; positive regulation of BMP signaling pathway; positive regulation of endothelial cell differentiation; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; protein heterooligomerization; regulation of blood pressure; regulation of transcription, DNA-dependent; signal transduction; transforming growth factor beta receptor signaling pathway; wound healing, spreading of epidermal cells
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Research Articles on ACVRL1

1. In vascular sprouting, neuropilin-1 suppresses the stalk-cell phenotype by limiting Smad2/3 activation through Alk1 and Alk5. Notch downregulates Nrp1, thus relieving the inhibition of Alk1 and Alk5, thereby driving stalk-cell behaviour.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ACVRL1 recombinant protein

 Reference Product  PubMed Publications
 Eng recombinant protein  >209 publications with ACVRL1 and Eng
 Smad1 recombinant protein  >61 publications with ACVRL1 and Smad1
 Tgfb1 recombinant protein  >48 publications with ACVRL1 and Tgfb1
 Smad4 recombinant protein  >43 publications with ACVRL1 and Smad4
 Gdf2 recombinant protein  >29 publications with ACVRL1 and Gdf2
 Smad5 recombinant protein  >21 publications with ACVRL1 and Smad5
 Bmp10 recombinant protein  >12 publications with ACVRL1 and Bmp10
 Bmp4 recombinant protein  >8 publications with ACVRL1 and Bmp4
 Smad9 recombinant protein  >6 publications with ACVRL1 and Smad9

Pathways associated with ACVRL1 recombinant protein

 Products by Pathway  Pathway Diagram
 Id Signaling Pathway antibodies  Id Signaling Pathway Diagram
 TGF-beta Receptor Signaling Pathway antibodies  TGF-beta Receptor Signaling Pathway Diagram
 XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway antibodies  XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway Diagram

Diseases associated with ACVRL1 recombinant protein

 Disease Name  Pubmed Publications
 Telangiectasia, Hereditary Hemorrhagic Antibodies  >227 publications with ACVRL1 and Telangiectasia, Hereditary Hemorrhagic
 Cardiovascular Diseases Antibodies  >221 publications with ACVRL1 and Cardiovascular Diseases
 Hypertension Antibodies  >67 publications with ACVRL1 and Hypertension
 Lung Diseases Antibodies  >62 publications with ACVRL1 and Lung Diseases
 Heart Diseases Antibodies  >25 publications with ACVRL1 and Heart Diseases
 Fibrosis Antibodies  >15 publications with ACVRL1 and Fibrosis
 Inflammation Antibodies  >15 publications with ACVRL1 and Inflammation
 Liver Diseases Antibodies  >11 publications with ACVRL1 and Liver Diseases
 Lung Neoplasms Antibodies  >10 publications with ACVRL1 and Lung Neoplasms
 Breast Neoplasms Antibodies  >9 publications with ACVRL1 and Breast Neoplasms

Organs/Tissues associated with ACVRL1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Other Antibodies  >90 publications with ACVRL1 and Other
 Brain Antibodies  >62 publications with ACVRL1 and Brain
 Lung Antibodies  >60 publications with ACVRL1 and Lung
 Heart Antibodies  >51 publications with ACVRL1 and Heart
 Muscle Antibodies  >43 publications with ACVRL1 and Muscle
 Liver Antibodies  >43 publications with ACVRL1 and Liver
 Skin Antibodies  >33 publications with ACVRL1 and Skin
 Embryonic Tissue Antibodies  >29 publications with ACVRL1 and Embryonic Tissue
 Kidney Antibodies  >15 publications with ACVRL1 and Kidney
 Bone Marrow Antibodies  >10 publications with ACVRL1 and Bone Marrow
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