Human AITRL Recombinant Protein – Cat# MBS142194

AITRL Human Recombinant Protein

Name: AITRL Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS142194
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS142194

Description: The Human AITRL His-Tagged Recombinant Protein, produced in E Coli, is 15.7 kDa (calculated) protein containing 125 amino acid residues of the human AITRL and 14 additional amino acid residues - HisTag (underlined). The amino acid sequence of the… More details

$250 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AITRL, Recombinant Protein

Full Product Name

Recombinant Human AITRL, His Tag

Product Gene Name

AITRL recombinant protein

Product Synonym Names

AITRL Human, His; AITRL Human Recombinant, His Tag; Osteostat; TNFSF18; Activation-induced TNFR member Ligand; GITRL; TL6; AITRL; Glucocorticoid-induced TNF-related ligand; hGITRL; Tumor necrosis factor ligand superfamily member 18; MGC138237; AITRL His

Sequence

MQLETAKEPC MAKFGPLPSK WQMASSEPPC VNKVSDWKLE ILQNGLYLIY GQVAPNANYN DVAPFEVRLY KNKDMIQTLT NKSKIQNVGG TYELHVGDTI DLIFNSEHQV LKNNTYWGII LIANPQEISL EHHHHHH

Host

E Coli

Form/Format

Lyophilized from 0.5 mg/ml in 0.03M Acetate buffer, pH-4.
Sterile Filtered White lyophilized (freeze-dried) powder.

Purity/Purification

Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Preparation and Storage

Lyophilized AITRL although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution AITRL should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Molecular Weight

22,724 Da

OMIM

603898

3D Structure

ModBase 3D Structure for Q9UNG2

Solubility

Add 0.2 ml of 0.1M Acetate buffer pH-4 and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10 ug/ml. In higher concentrations the solubility of this antigen is limited.

Product Categories/Family for AITRL recombinant protein

Cytokines and Growth Factors; Cytokines; AITRL

Other Notes

Small volumes of AITRL recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AITRL purchase

MBS142194 is a recombinant protein targeting AITRL. Also known as Recombinant Human AITRL, His Tag. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for AITRL. It may not necessarily be applicable to this product.

NCBI GI #

157419142

NCBI GeneID

8995

NCBI Accession #

NP_005083.2

UniProt Primary Accession #

Q9UNG2

UniProt Secondary Accession #

O95852; Q6ISV1; A9IQG8

UniProt Related Accession #

Q9UNG2

GenBank Nucleotide #

NM_005092.3

NCBI Official Full Name

tumor necrosis factor ligand superfamily member 18

NCBI Official Synonym Full Names

tumor necrosis factor (ligand) superfamily, member 18

NCBI Official Symbol

TNFSF18

NCBI Official Synonym Symbols

TL6; AITRL; GITRL; hGITRL

UniProt Protein Name

Tumor necrosis factor ligand superfamily member 18

UniProt Synonym Protein Names

Activation-inducible TNF-related ligand; AITRL; Glucocorticoid-induced TNF-related ligand; hGITRL

Protein Family

Tumor necrosis factor ligand superfamily

UniProt Gene Name

TNFSF18

UniProt Synonym Gene Names

AITRL; GITRL; TL6; AITRL; hGITRL

UniProt Entry Name

TNF18_HUMAN

NCBI Protein Information

tumor necrosis factor ligand superfamily member 18; AITR ligand; GITR ligand; activation-inducible TNF-related ligand; glucocorticoid-induced TNF-related ligand; glucocorticoid-induced TNFR-related protein ligand

NCBI Summary for AITRL

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008]

UniProt Comments for AITRL

TNFSF18: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T- cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Belongs to the tumor necrosis factor family.

Protein type: Membrane protein, integral; Apoptosis; Cytokine

Chromosomal Location of Human Ortholog: 1q23

Cellular Component: extracellular space; cell surface; plasma membrane; integral to membrane

Molecular Function: cytokine activity; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding; receptor binding

Biological Process: tumor necrosis factor-mediated signaling pathway; cell-cell signaling; T cell proliferation during immune response; regulation of T cell proliferation; signal transduction; negative regulation of apoptosis; activation of NF-kappaB transcription factor

Research Articles on AITRL

1. Our findings indicate the possible involvement of GITR-GITRL pathway in the pathogenesis of pSS.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with AITRL recombinant protein

Reference Product	PubMed Publications
TNFRSF18 recombinant protein	>52 publications with AITRL and TNFRSF18
CD4 recombinant protein	>42 publications with AITRL and CD4
IL2RA recombinant protein	>5 publications with AITRL and IL2RA
ICOSLG recombinant protein	>4 publications with AITRL and ICOSLG
TNFRSF4 recombinant protein	>1 publications with AITRL and TNFRSF4

Pathways associated with AITRL recombinant protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram

Diseases associated with AITRL recombinant protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>101 publications with AITRL and Necrosis
Inflammation Antibodies	>19 publications with AITRL and Inflammation
Neoplasms, Experimental Antibodies	>9 publications with AITRL and Neoplasms, Experimental
Disease Models, Animal Antibodies	>8 publications with AITRL and Disease Models, Animal
Carcinoma, Hepatocellular Antibodies	>2 publications with AITRL and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>2 publications with AITRL and Liver Neoplasms
Atherosclerosis Antibodies	>2 publications with AITRL and Atherosclerosis
Breast Neoplasms Antibodies	>2 publications with AITRL and Breast Neoplasms
Lung Diseases Antibodies	>1 publications with AITRL and Lung Diseases
Lung Injury Antibodies	>1 publications with AITRL and Lung Injury

Organs/Tissues associated with AITRL recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>4 publications with AITRL and Brain
Vascular Antibodies	>4 publications with AITRL and Vascular
Muscle Antibodies	>3 publications with AITRL and Muscle
Mixed Antibodies	>2 publications with AITRL and Mixed