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RANGRF Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS204366

RANGRF is a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants.… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
RANGRF, Recombinant Protein
Full Product Name
RANGRF, 1-186aa, Human, His tag, E Coli
Product Synonym Names
RAN guanine nucleotide release factor; HSPC165; HSPC236; MOG1; RANGNRF
Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMEPTRD CPLFGGAFSA ILPMGAIDVS DLRPVPDNQE VFCHPVTDQS LIVELLELQA HVRGEAAARY HFEDVGGVQG ARAVHVESVQ PLSLENLALR GRCQEAWVLS GKQQIAKENQ QVAKDVTLHQ ALLRLPQYQT DLLLTFNQPP PDNRSSLGPE NLSPAPWSLG DFEQLVTSLT LHDPNIFGPQ
Host
E Coli
Form/Format
Liquid. 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol 0.15M NaCl, 1mM DTT
Purity/Purification
> 90% by SDS-PAGE
Concentration
1 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
23.0kDa (210aa), confirmed by MALDI-TOF
OMIM
AF265205 mRNA
3D Structure
ModBase 3D Structure for Q9HD47
Antigen Species
Human
Tag Information
His-tag

Product Categories/Family for RANGRF recombinant protein

Applications Tested/Suitable for RANGRF recombinant protein
SDS-PAGE

Product References and Citations for RANGRF recombinant protein

Olesen,M.S., et al. (2011) Can J Cardiol 27 (4), 523; Kattygnarath,D., et al. (2011) Circ Cardiovasc Genet 4 (3), 261-268.

Other Notes

Small volumes of RANGRF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RANGRF purchase

MBS204366 is a recombinant protein targeting RANGRF. Also known as RANGRF, 1-186aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for RANGRF. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
ran guanine nucleotide release factor isoform A
NCBI Official Synonym Full Names
RAN guanine nucleotide release factor
NCBI Official Symbol
RANGRF
NCBI Official Synonym Symbols
MOG1; HSPC165; HSPC236; RANGNRF
UniProt Protein Name
Ran guanine nucleotide release factor
UniProt Synonym Protein Names
Ran-binding protein MOG1
UniProt Gene Name
RANGRF
UniProt Synonym Gene Names
MOG1; RANGNRF; RanGNRF
NCBI Protein Information
ran guanine nucleotide release factor

NCBI Summary for RANGRF

This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

UniProt Comments for RANGRF

May regulate the intracellular trafficking of RAN (PubMed:11290418). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:29040603). Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (PubMed:29040603). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:23420830, PubMed:21621375).
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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