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DRAM Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS840905

Background: Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been smuggested that activation of DRAM by p53 is simultaneous… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
DRAM, Polyclonal Antibody
Full Product Name
DRAM Antibody (NT)
Product Gene Name
Product Synonym Names
Damage-regulated autophagy modulator
Clonality
Polyclonal
Isotype
IgG1
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
100 ug (1 mg/ml) in 1X PBS containing 0.02% sodium azide.
Appearance: Colorless liquid
Purity/Purification
Affinity chromatography purified via peptide column.
Concentration
1 mg/ml (lot specific)
Preparation and Storage
At -20 degree C
Shelf Life: 12 months
Molecular Weight
13,972 Da
OMIM
610776
3D Structure
ModBase 3D Structure for Q8N682
Immunogen
DRAM antibody was raised against a 16 amino acid peptide from near the amino terminus of human DRAM.
Positive Control
Western Blot: K562 cell lysateImmunohistochemistry: Human liver tissue
Handling
The antibody solution should be gently mixed before use.
Applications Tested/Suitable for anti-DRAM antibody
Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA)
Application Notes for anti-DRAM antibody
Western Blot: 0.5-2 mug/ml, Immunohistochemistry: 2.5 mug/ml, ELISA. However, the optimal conditions should be determined individually.

Testing Data of anti-DRAM antibody

Rabbit Anti-DRAM Polyclonal Antibody – Cat# MBS840905

Other Notes

Small volumes of anti-DRAM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DRAM purchase

MBS840905 is an antibody targeting DRAM. Also known as DRAM Antibody (NT). Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DRAM. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
DNA damage-regulated autophagy modulator protein 1
NCBI Official Synonym Full Names
DNA-damage regulated autophagy modulator 1
NCBI Official Symbol
DRAM1
NCBI Official Synonym Symbols
DRAM
UniProt Protein Name
DNA damage-regulated autophagy modulator protein 1
UniProt Synonym Protein Names
Damage-regulated autophagy modulator
UniProt Gene Name
DRAM1
UniProt Synonym Gene Names
DRAM
UniProt Entry Name
DRAM1_HUMAN
NCBI Protein Information
DNA damage-regulated autophagy modulator protein 1

NCBI Summary for DRAM

This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. [provided by RefSeq, Jul 2008]
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UniProt Comments for DRAM

DRAM1: Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73- mediated autophagy. Belongs to the DRAM/TMEM150 family.

Protein type: Apoptosis; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 12q23.2

Cellular Component: lysosome; lysosomal membrane; cytoplasm; integral to membrane

Biological Process: apoptosis; autophagy; regulation of autophagy
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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