Human EIF4G3 cDNA Clone Expression Plasmid – Cat# MBS1271590

EIF4G3 cDNA Clone – Eukaryotic Translation Initiation Factor 4 Gamma, 3 (Human)

Name: EIF4G3 cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1271590
Price: 605 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1271590

MBS1271590 is a cDNA clone targeting EIF4G3. More details

$605 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

EIF4G3, cDNA Clone

Full Product Name

EIF4G3 cDNA Clone

Product Gene Name

EIF4G3 cdna clone

Sequence

atgaattcac aacctcaaac ccgttctccg tttgcagcgg ggcctcgacc tccccatcat cagtttttcc agaggcctca aatacagcct cctagagcta ccatcccgaa cagcagtcct tccattcgtc ctggtgcaca gacacccact gcagtgtacc aggctaatca gcacatcatg atggttaacc atctgcccat gccgtaccca gtgccccagg ggcctcagta ctgtatacca cagtaccgtc atagtggccc tccttatgtt gggccccccc aacaatatcc agttcaacca ccggggccag gtccttttta tcctggacca ggacctgggg acttccccaa tgcttatgga acgccttttt acccaagtca gccggtgtat cagtcagcac ctatcatagt gcctacgcag caacagccgc ctccagccaa gagagagaaa aaaactataa gaattcggga tccaaaccag ggaggtaaag acataacaga ggagattata tctggaggtg gcagcagaaa tcctactcca cccataggaa gacccacgtc cacacctact cctcctcagc agctgcccag ccaggtcccc gagcacagcc ctgtggttta tgggactgtg gagagcgctc atcttgctgc cagcacccct gtcactgcag ctagcgacca gaagcaagag gagaagccaa aaccagatcc agtgttaaag tctccttccc cagtccttag gctagtcctc agtggagaga agaaagaaca agaaggccag acatctgaaa ctactgcaat agtatccata gcagagcttc ctctgcctcc atcacctacc actgtttctt ctgttgctcg aagtacaatt gcagccccca cctcttctgc tcttagtagc caaccaatat tcaccactgc tatagatgac aggtgtgaac tctcatcccc aagagaagac acaattccta tacccagcct cacatcttgc acagaaacat cagacccttt accaacaaat gaaaatgatg gtgatatatg caagaaaccc tgtagtgtag cacctaatga tattccactg gtttctagta ctaacctaat taatgaaata aatggagtta gcgaaaaatt atcagccacg gagagcattg tggaaatagt aaaacaggaa gtattgccat tgactcttga attggagatt ctcgaaaatc ccccagaaga aatgaaactg gagtgtatcc cagctcccat caccccttcc acagttcctt cctttcctcc aactcctcca actcctccag cttctcctcc tcacactcca gtcattgttc ctgctgctgc cactactgtt agttctccga gtgctgccat cacagtccag agagtcctag aggaggacga gagcataaga acttgcctta gtgaagatgc aaaagagatt cagaacaaaa tagaggtaga agcagatggg caaacagaag agattttgga ttctcaaaac ttaaattcaa gaaggagccc tgtcccagaa acatcgaatg aatgctga

Molecular Weight

146,871 Da

OMIM

603929

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of EIF4G3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for EIF4G3. It may not necessarily be applicable to this product.

NCBI GI #

22539617

NCBI GeneID

8672

NCBI Accession #

BC030578

UniProt Secondary Accession #

Q15597; Q504Z1; Q5SWC3; Q8NEN1; B9EGQ7

UniProt Related Accession #

O43432

NCBI Official Full Name

Homo sapiens eukaryotic translation initiation factor 4 gamma, 3, mRNA

NCBI Official Synonym Full Names

eukaryotic translation initiation factor 4 gamma 3

NCBI Official Symbol

EIF4G3

NCBI Official Synonym Symbols

eIF4G 3; eIF4GII; eIF-4G 3

UniProt Protein Name

Eukaryotic translation initiation factor 4 gamma 3

UniProt Synonym Protein Names

eIF-4-gamma II; eIF4GII

Protein Family

Eukaryotic translation initiation factor

UniProt Gene Name

EIF4G3

UniProt Synonym Gene Names

eIF-4-gamma 3; eIF-4G 3; eIF4G 3; eIF4GII

UniProt Entry Name

IF4G3_HUMAN

NCBI Protein Information

eukaryotic translation initiation factor 4 gamma 3

NCBI Summary for EIF4G3

The protein encoded by this gene is thought to be part of the eIF4F protein complex, which is involved in mRNA cap recognition and transport of mRNAs to the ribosome. Interestingly, a microRNA (miR-520c-3p) has been found that negatively regulates synthesis of the encoded protein, and this leads to a global decrease in protein translation and cell proliferation. Therefore, this protein is a key component of the anti-tumor activity of miR-520c-3p. [provided by RefSeq, May 2016]

UniProt Comments for EIF4G3

EIF4G3: Probable component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. Thought to be a functional homolog of EIF4G1. Interacts with EIF4A, EIF4E, eIF3 and PABPC1. Part of a complex with EIF4E. eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. EIF4G1/EIF4G3 interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate eIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIFG3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. Belongs to the eIF4G family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Translation initiation; Translation; RNA-binding

Chromosomal Location of Human Ortholog: 1p36.12

Cellular Component: cytosol; eukaryotic translation initiation factor 4F complex

Molecular Function: RNA cap binding; translation factor activity, nucleic acid binding

Biological Process: regulation of translational initiation

Research Articles on EIF4G3

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with EIF4G3 cdna clone

Products by Pathway	Pathway Diagram
Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies	Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
ISG15 Antiviral Mechanism Pathway antibodies	ISG15 Antiviral Mechanism Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Interferon Signaling Pathway antibodies	Interferon Signaling Pathway Diagram
RNA Transport Pathway antibodies	RNA Transport Pathway Diagram
RNA Transport Pathway antibodies	RNA Transport Pathway Diagram
Translation Factors Pathway antibodies	Translation Factors Pathway Diagram
Viral Myocarditis Pathway antibodies	Viral Myocarditis Pathway Diagram
EIF4F Complex Pathway antibodies	EIF4F Complex Pathway Diagram

Organs/Tissues associated with EIF4G3 cdna clone

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>3 publications with EIF4G3 and Blood