EYA2 siRNA – Eyes Absent Homolog 2 Isoform a (Human)

This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Alternative splicing results in multiple transcript variants, but the full-length natures of all of these variants have not yet been determined. [provided by RefSeq, Jul 2009]

EYA2: Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1. Seems to coactivate SIX2, SIX4 and SIX5. Together with SIX1 and DACH2 seem to be involved in myogenesis. May be involved in development of the eye. Interaction with GNAZ and GNAI2 prevents nuclear translocation and transcriptional activity. Belongs to the HAD-like hydrolase superfamily. EYA family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein phosphatase, tyrosine (non-receptor); Cell development/differentiation; EC 3.1.3.48; Apoptosis

Chromosomal Location of Human Ortholog: 20q13.1

Cellular Component: centrosome; mitochondrion; cytoplasm; nucleus

Molecular Function: protein binding; magnesium ion binding; protein tyrosine phosphatase activity

Biological Process: histone dephosphorylation; striated muscle development; regulation of transcription, DNA-dependent; transcription, DNA-dependent; mesodermal cell fate specification; DNA repair