ACVR2B siRNA – Activin Receptor Type-2b (Mouse)

ACVR2B: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active. The IIB receptor displays a 3- to 4-fold higher affinity for activin A than the II receptor.

Protein type: Membrane protein, integral; EC 2.7.11.30; Kinase, protein; Protein kinase, TKL; Protein kinase, Ser/Thr (receptor); TKL group; STKR family; Type2 subfamily

Cellular Component: protein complex; membrane; cell; cytoplasm; integral to membrane; plasma membrane; receptor complex

Molecular Function: metal ion binding; nucleotide binding; transmembrane receptor protein serine/threonine kinase activity; protein kinase activity; transferase activity; protein serine/threonine kinase activity; protein binding; transforming growth factor beta binding; growth factor binding; transferase activity, transferring phosphorus-containing groups; protein serine/threonine/tyrosine kinase activity; activin binding; kinase activity; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: heart development; regulation of signal transduction; palate development; signal transduction; protein amino acid phosphorylation; post-embryonic development; BMP signaling pathway; anterior/posterior pattern formation; positive regulation of activin receptor signaling pathway; regulation of transcription, DNA-dependent; lymphangiogenesis; transmembrane receptor protein serine/threonine kinase signaling pathway; pancreas development; embryonic foregut morphogenesis; response to glucose stimulus; mesoderm development; kidney development; skeletal development; gastrulation with mouth forming second; positive regulation of bone mineralization; pattern specification process; odontogenesis of dentine-containing teeth; organ growth; positive regulation of osteoblast differentiation; insulin secretion; skeletal morphogenesis; activation of protein kinase activity; blood vessel remodeling; determination of left/right symmetry; phosphorylation; lung development