Rabbit Anti-APLNR Polyclonal Antibody – Cat# MBS6274358

APLNR Antibody (Center) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the APLNR antibody detected the APLNR protein (arrow).

APLNR Antibody – Rabbit Polyclonal

Name: APLNR Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6274358
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6274358

This gene encodes a member of the G protein-coupled receptor gene family. The encoded protein is related to the angiotensin receptor, but is actually an apelin receptor that inhibits adenylate cyclase activity and plays a counter-regulatory role against the… More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

APLNR, Polyclonal Antibody

Full Product Name

APLNR, ID (APLNR, AGTRL1, APJ, Apelin receptor, Angiotensin receptor-like 1, G-protein coupled receptor APJ, G-protein coupled receptor HG11) (APC)

Product Gene Name

anti-APLNR antibody

Product Synonym Names

APLNR; AGTRL1; APJ; Apelin receptor; Angiotensin receptor-like 1; G-protein coupled receptor APJ; G-protein coupled receptor HG11

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

42,660 Da

Chromosome Location

Chromosome: 11; NC_000011.9 (57001051..57004927, complement). Location: 11q12

OMIM

600052

3D Structure

ModBase 3D Structure for P35414

Immunogen

APLNR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 214-244 amino acids from the Central region of human APLNR.

Conjugate

APC

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-APLNR antibody

Antibodies; Angiotensin(ogen)

Applications Tested/Suitable for anti-APLNR antibody

Western Blot (WB), FLISA

Application Notes for anti-APLNR antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-APLNR antibody

Tao, Y., et al. Invest. Ophthalmol. Vis. Sci. 51(8):4237-4242(2010). Zhao, Q., et al. Am. J. Hypertens. 23(6):606-613(2010). Lee, D.K., et al. Biochem. Biophys. Res. Commun. 395(2):185-189(2010). Falcao-Pires, I., et al. Expert Opin. Ther. Targets 14(3):231-241(2010). Peltonen, T., et al. J. Heart Valve Dis. 18(6):644-652(2009).

Other Notes

Small volumes of anti-APLNR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for APLNR purchase

MBS6274358 is an antibody targeting APLNR. Also known as APLNR, ID (APLNR, AGTRL1, APJ, Apelin receptor, Angiotensin receptor-like 1, G-protein coupled receptor APJ, G-protein coupled receptor HG11) (APC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for APLNR. It may not necessarily be applicable to this product.

NCBI GI #

4885057

NCBI GeneID

187

NCBI Accession #

NP_005152.1

UniProt Primary Accession #

P35414

UniProt Related Accession #

P35414

GenBank Nucleotide #

NM_005161.4

NCBI Official Full Name

apelin receptor

NCBI Official Synonym Full Names

apelin receptor

NCBI Official Symbol

APLNR

NCBI Official Synonym Symbols

APJ; APJR; HG11; AGTRL1

UniProt Protein Name

Apelin receptor

UniProt Synonym Protein Names

Angiotensin receptor-like 1; G-protein coupled receptor APJ; G-protein coupled receptor HG11

Protein Family

Apelin receptor

UniProt Gene Name

APLNR

UniProt Synonym Gene Names

AGTRL1; APJ

UniProt Entry Name

APJ_HUMAN

NCBI Protein Information

apelin receptor; APJ receptor; HG11 orphan receptor; APJ (apelin) receptor; angiotensin receptor-like 1; G protein-coupled receptor APJ; G-protein coupled receptor APJ; angiotensin II receptor-like 1; G-protein coupled receptor HG11

UniProt Comments for APLNR

AGTRL1: Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 11q12

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity; receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; regulation of body fluid levels; heart development; gastrulation

Research Articles on APLNR

1. Interactive effects of genetic defects in apelin/APJ pathway might confer a potential risk in Chinese hypertensive patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-APLNR antibody

Reference Product	PubMed Publications
APLN antibody	>138 publications with APLNR and APLN

Pathways associated with anti-APLNR antibody

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram

Diseases associated with anti-APLNR antibody

Disease Name	Pubmed Publications
Heart Diseases Antibodies	>33 publications with APLNR and Heart Diseases
Hypertension Antibodies	>27 publications with APLNR and Hypertension
Disease Models, Animal Antibodies	>15 publications with APLNR and Disease Models, Animal
Nervous System Diseases Antibodies	>12 publications with APLNR and Nervous System Diseases
Hypertrophy Antibodies	>9 publications with APLNR and Hypertrophy
Immune System Diseases Antibodies	>9 publications with APLNR and Immune System Diseases
Brain Diseases Antibodies	>8 publications with APLNR and Brain Diseases
Arteriosclerosis Antibodies	>8 publications with APLNR and Arteriosclerosis
Lung Diseases Antibodies	>7 publications with APLNR and Lung Diseases
Inflammation Antibodies	>7 publications with APLNR and Inflammation

Organs/Tissues associated with anti-APLNR antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>79 publications with APLNR and Blood
Heart Antibodies	>56 publications with APLNR and Heart
Brain Antibodies	>37 publications with APLNR and Brain
Lung Antibodies	>16 publications with APLNR and Lung
Kidney Antibodies	>15 publications with APLNR and Kidney
Embryonic Tissue Antibodies	>12 publications with APLNR and Embryonic Tissue
Connective Tissue Antibodies	>10 publications with APLNR and Connective Tissue
Adipose Tissue Antibodies	>10 publications with APLNR and Adipose Tissue
Eye Antibodies	>7 publications with APLNR and Eye
Ovary Antibodies	>6 publications with APLNR and Ovary