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CAPZB Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6466966

MBS6466966 is an antibody targeting CAPZB. Also known as CAPZB, NT (F-actin-capping Protein Subunit beta, CapZ beta) (APC). Reactive in Human. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CAPZB, Polyclonal Antibody
Full Product Name
CAPZB, NT (F-actin-capping Protein Subunit beta, CapZ beta) (APC)
Product Gene Name
anti-CAPZB antibody
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Immunoaffinity chromatography.
Specificity
Recognizes human CAPZB.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Do not freeze APC conjugates. Light sensitive. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
– Da
3D Structure
ModBase 3D Structure for P47756
Immunogen
Synthetic peptide selected from the N-terminal region of human CAPZB (KLH).
Conjugate
APC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-CAPZB antibody

Antibodies; Growth Factors; Cytokines
Applications Tested/Suitable for anti-CAPZB antibody
Western Blot (WB), FLISA
Application Notes for anti-CAPZB antibody
WB: 1:100-1:500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-CAPZB antibody

Western blot analysis of CAPZB (arrow) using rabbit polyclonal CAPZB Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CAPZB gene (Lane 2).
Rabbit Anti-CAPZB Polyclonal Antibody – Cat# MBS6466966

Western Blot (WB) of anti-CAPZB antibody

Dictyostelium discoideum FAM21 contains a Capping Protein the interaction site (CPI) at amino acids 1201---1217. A construct was created where this site was removed from FAM21, and both the full length and FAM21ΔCPI were tagged with GFP and expressed in D.discoideum cells. GFP---trap beads were used to purify both constructs and western blotting was used to detect the presence of CAP32 (D. discoideum Capping Protein subunit). A GFP only construct was used as a control.It is shown here that CAP32 is pulled down with the full length protein but not when the interaction site is removed.
Rabbit Anti-CAPZB Polyclonal Antibody, Western Blot (WB) – Cat# MBS6466966

Product References and Citations for anti-CAPZB antibody

1. Wells, C.D., Cell 125(3), 535-548 (2006). 2. Bruneel, A., Proteomics 5(15), 3876-3884 (2005).

Other Notes

Small volumes of anti-CAPZB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CAPZB. It may not necessarily be applicable to this product.

NCBI GI #
4826659
NCBI GeneID
832
NCBI Accession #
NP_004921
UniProt Primary Accession #
P47756
UniProt Secondary Accession #
Q32Q68; Q5U0L4; Q8TB49; Q9NUC4
UniProt Related Accession #
P47756
GenBank Nucleotide #
NM_004930.4
NCBI Official Full Name
F-actin-capping protein subunit beta isoform 1
NCBI Official Synonym Full Names
capping protein (actin filament) muscle Z-line, beta
NCBI Official Symbol
CAPZB
NCBI Official Synonym Symbols
CAPB; CAPZ; CAPPB
UniProt Protein Name
F-actin-capping protein subunit beta
UniProt Synonym Protein Names
CapZ beta
Protein Family
F-actin-capping protein
UniProt Gene Name
CAPZB
NCBI Protein Information
F-actin-capping protein subunit beta

NCBI Summary for CAPZB

This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Aug 2013]
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UniProt Comments for CAPZB

F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization.
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Research Articles on CAPZB

1. RAGE has a role in endothelial cell membrane repair and regulates F-actin remodeling and membrane resealing

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CAPZB antibody

 Reference Product  PubMed Publications
 CAPZA1 antibody  >1 publications with CAPZB and CAPZA1
 CAPZA2 antibody  >1 publications with CAPZB and CAPZA2

Pathways associated with anti-CAPZB antibody

 Products by Pathway  Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram

Diseases associated with anti-CAPZB antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2 publications with CAPZB and Inflammation
 Immune System Diseases Antibodies  >1 publications with CAPZB and Immune System Diseases
 Atrophy Antibodies  >1 publications with CAPZB and Atrophy
 Atherosclerosis Antibodies  >1 publications with CAPZB and Atherosclerosis
 Nervous System Diseases Antibodies  >1 publications with CAPZB and Nervous System Diseases
 Carcinoma Antibodies  >1 publications with CAPZB and Carcinoma

Organs/Tissues associated with anti-CAPZB antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >6 publications with CAPZB and Muscle
 Thyroid Antibodies  >6 publications with CAPZB and Thyroid
 Blood Antibodies  >4 publications with CAPZB and Blood
 Nerve Antibodies  >1 publications with CAPZB and Nerve
 Vascular Antibodies  >1 publications with CAPZB and Vascular
 Heart Antibodies  >1 publications with CAPZB and Heart
 Kidney Antibodies  >1 publications with CAPZB and Kidney
 Eye Antibodies  >1 publications with CAPZB and Eye
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