ATOH1 Antibody – Rabbit Polyclonal

ATOH1: a conserved transcription factor that regulates secretory cell differentiation in colonic epithelium. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. May play a role in the differentiation of subsets of neural cells by activating E box- dependent transcription . Efficient DNA binding requires dimerization with another bHLH protein. Loss of ATOH1 expression in the colon of mice initiates colon cancer. ATOH1 has been silenced in most human colon cancers, and reactivation of this gene in cultured human colon cancer cells is anti-proliferative and induces apoptosis.

Protein type: Transcription factor; Cell development/differentiation; DNA-binding

Cellular Component: nucleus

Molecular Function: chromatin DNA binding; DNA binding; protein binding; protein dimerization activity; sequence-specific DNA binding

Biological Process: auditory receptor cell differentiation; auditory receptor cell fate determination; auditory receptor cell fate specification; axon guidance; brain development; cell differentiation; cerebral cortex development; inner ear development; inner ear morphogenesis; multicellular organismal development; negative regulation of apoptosis; nervous system development; neuron differentiation; neuron migration; Notch signaling pathway; positive regulation of auditory receptor cell differentiation; positive regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of neuron differentiation; regulation of transcription, DNA-dependent; transcription, DNA-dependent