P2RX2 siRNA – P2X Purinoceptor 2 (Rat)

P2X2: Binding of this ligand-gated ion channel to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Belongs to the P2X receptor family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, ligand-gated; Membrane protein, integral; Channel, cation; Membrane protein, multi-pass

Cellular Component: cell surface; integral to plasma membrane; postsynaptic density; integral to membrane; dendritic spine; terminal button; integral to nuclear inner membrane; presynaptic membrane; membrane; cell soma; apical plasma membrane; plasma membrane; intracellular; receptor complex

Molecular Function: identical protein binding; zinc ion binding; mercury ion binding; ion channel activity; drug binding; ligand-gated ion channel activity; cadmium ion binding; nickel ion binding; purinergic nucleotide receptor activity; phosphoinositide binding; protein binding; copper ion binding; cobalt ion binding; ATP binding; ATP-gated cation channel activity

Biological Process: urinary bladder smooth muscle contraction; peristalsis; sensory perception of taste; protein heterooligomerization; generation of action potential; skeletal muscle fiber development; detection of hypoxic conditions in blood by carotid body chemoreceptors; response to carbohydrate stimulus; response to ATP; response to organic substance; synaptic transmission; behavioral response to pain; sensory perception of sound; response to hypoxia; neuromuscular synaptic transmission; cation transport; protein homooligomerization; neuromuscular junction development