Human C6 Recombinant Protein – Cat# MBS2545514

C6 / Complement Component 6 (C6) Human Recombinant Protein

Name: C6 Recombinant Protein; C6 / Complement Component 6; Human; MyBioSource
Brand: MyBioSource
SKU: MBS2545514
Price: 370 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2545514

Neuromodulin, also known as Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-50, pp46 and GAP43, is a cell membrane protein which belongs to the neuromodulin family. Neuromodulin / GAP43 contains oneIQ domain. Neuromodulin… More details

$370 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

C6 / complement component 6, Recombinant Protein

Full Product Name

Recombinant Human C6 / complement component 6 Protein (His tag)

Product Gene Name

C6 recombinant protein

Product Synonym Names

Host

HEK293 Cells

Form/Format

Lyophilized from sterile PBS, pH 7.4, 5% trehalose, 5% mannitol, 0.01% Tween80

Purity/Purification

> 90% as determined by reducing SDS-PAGE

Preparation and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C.
Reconstituted protein solution can be stored at 4 to 8°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Molecular Weight

Molecular Mass: 104 kDa
Actual Protein Molecular Mass: 110 kDa

OMIM

J05064 mRNA

Species

Human

Sequence

Met 1-Ala 934

Tag

C-His

Endotoxin

< 1.0 EU per ug of the protein as determined by the LAL method

Reconstitution

We recommend centrifuging the vial before opening to bring the contents to the bottom. Do not mix by vortex. It is recommended that sterile water be added to the vial to prepare a stock solution of 0.25 mg/mL. Concentration is measured by UV-Vis.

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of C6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for C6 purchase

MBS2545514 is a recombinant protein targeting C6. Also known as Recombinant Human C6 / complement component 6 Protein (His tag). Host: HEK293 Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for C6. It may not necessarily be applicable to this product.

NCBI GI #

307228

NCBI GeneID

729

NCBI Accession #

AAA59668.1

UniProt Related Accession #

P13671

NCBI Official Full Name

completement component C6

NCBI Official Synonym Full Names

complement C6

NCBI Official Symbol

UniProt Protein Name

Complement component C6

Protein Family

Complement component

UniProt Gene Name

NCBI Protein Information

complement component C6

NCBI Summary for C6

This gene encodes a component of the complement cascade. The encoded protein is part of the membrane attack complex that can be incorporated into the cell membrane and cause cell lysis. Mutations in this gene are associated with complement component-6 deficiency. Transcript variants encoding the same protein have been described.[provided by RefSeq, Nov 2012]

UniProt Comments for C6

C6: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Defects in C6 are the cause of complement component 6 deficiency (C6D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5p13.1

Cellular Component: extracellular region

Molecular Function: protein binding

Biological Process: complement activation; regulation of complement activation

Disease: Complement Component 6 Deficiency

Research Articles on C6

1. recipient C6 rs9200 polymorphism is associated with HCC recurrence after OLT, and improves the predictive value of clinical models.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with C6 recombinant protein

Reference Product	PubMed Publications
CD59 recombinant protein	>25 publications with C6 and CD59
C8G recombinant protein	>10 publications with C6 and C8G
C8B recombinant protein	>6 publications with C6 and C8B
PSMA2 recombinant protein	>1 publications with C6 and PSMA2
PSMA3 recombinant protein	>1 publications with C6 and PSMA3
PSMA4 recombinant protein	>1 publications with C6 and PSMA4
PSMA6 recombinant protein	>1 publications with C6 and PSMA6
PSMA1 recombinant protein	>1 publications with C6 and PSMA1

Pathways associated with C6 recombinant protein

Products by Pathway	Pathway Diagram
Complement Activation Pathway antibodies	Complement Activation Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement Cascade Pathway antibodies	Complement Cascade Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Prion Diseases Pathway antibodies	Prion Diseases Pathway Diagram
Prion Diseases Pathway antibodies	Prion Diseases Pathway Diagram
Regulation Of Complement Cascade Pathway antibodies	Regulation Of Complement Cascade Pathway Diagram

Diseases associated with C6 recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>3591 publications with C6 and Nervous System Diseases
Brain Diseases Antibodies	>1780 publications with C6 and Brain Diseases
Cardiovascular Diseases Antibodies	>644 publications with C6 and Cardiovascular Diseases
Disease Models, Animal Antibodies	>608 publications with C6 and Disease Models, Animal
Necrosis Antibodies	>442 publications with C6 and Necrosis
Inflammation Antibodies	>346 publications with C6 and Inflammation
Immune System Diseases Antibodies	>344 publications with C6 and Immune System Diseases
Edema Antibodies	>190 publications with C6 and Edema
Congenital Abnormalities Antibodies	>167 publications with C6 and Congenital Abnormalities
Kidney Diseases Antibodies	>155 publications with C6 and Kidney Diseases

Organs/Tissues associated with C6 recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>549 publications with C6 and Liver
Kidney Antibodies	>429 publications with C6 and Kidney
Heart Antibodies	>353 publications with C6 and Heart
Lung Antibodies	>301 publications with C6 and Lung
Connective Tissue Antibodies	>287 publications with C6 and Connective Tissue
Bladder Antibodies	>88 publications with C6 and Bladder
Pancreas Antibodies	>44 publications with C6 and Pancreas
Testis Antibodies	>35 publications with C6 and Testis
Uterus Antibodies	>19 publications with C6 and Uterus
Uncharacterized Tissue Antibodies	>1 publications with C6 and Uncharacterized Tissue