Human NSMCE4A cDNA Clone Expression Plasmid – Cat# MBS1276253

NSMCE4A cDNA Clone – Non-SMC Element 4 Homolog A (S. Cerevisiae) (Human)

Name: NSMCE4A cDNA Clone; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1276253
Price: 400 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1276253

MBS1276253 is a cDNA clone targeting NSMCE4A. More details

$400 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NSMCE4A, cDNA Clone

Full Product Name

NSMCE4A cDNA Clone

Product Gene Name

NSMCE4A cdna clone

Sequence

atgtctgggg acagcagcgg ccgcgggcca gagggccggg gccggggccg cgacccgcat cgggatcgca cccgctcccg ctcccgctcg cggtcccctt tgtcgcccag gtcccgccgc ggctctgcgc gggagcgcag agaggcccca gagcgcccga gcctggagga cacagagccg tcggattccg gggacgagat gatggacccg gccagcttgg aggcggaggc cgaccaaggc ctgtgccgcc agatccgcca tcagtaccgg gcgctcatca actccgtcca acaaaaccgt gaggacatac tgaatgccgg tgacaaatta acagaggtcc ttgaagaggc taacactctg tttaatgaag tgtcccgagc aagagaagca gtcctggatg cccactttct tgttttggct tcagatttgg gcaaagagaa agcaaagcag ctgcgctcag acctgagctc ctttgacatg ttaagatatg ttgaaactct actcacacat atgggtgtaa atccgctaga agctgaagaa ctcatccgtg atgaagatag tcctgatttt gaattcatag tctatgactc ctggaagata acaggcagaa cagcagaaaa cacctttaat aaaacccata cattccactt tctgttgggt tcaatatacg gagagtgccc tgtgccaaag ccacgagttg atcgtccaag aaaagttcct gtgatacaag aggagagggc aatgcctgcc cagttaagaa gaatggaaga atctcatcaa gaagcaacag agaaagaagt agaaagaatc ttgggattgt tgcagacata ttttcgagaa gatcgagaca gtctcactct ttcgcccaga ctggaatgca gtggcaccat ctcaactcac tgcaacctcc acctcctgga ttcaagcaat tctcctgcct cagcctcctg a

Molecular Weight

35,859 Da

OMIM

612987

Vector

Please Inquire

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of NSMCE4A cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NSMCE4A. It may not necessarily be applicable to this product.

NCBI GI #

13528824

NCBI GeneID

54780

NCBI Accession #

BC005212

UniProt Secondary Accession #

Q5SQQ5; Q6P673; Q8WY66; Q9BS90

UniProt Related Accession #

Q9NXX6

NCBI Official Full Name

Homo sapiens non-SMC element 4 homolog A (S. cerevisiae), mRNA

NCBI Official Synonym Full Names

NSE4 homolog A, SMC5-SMC6 complex component

NCBI Official Symbol

NSMCE4A

NCBI Official Synonym Symbols

NS4EA; NSE4A; C10orf86

UniProt Protein Name

Non-structural maintenance of chromosomes element 4 homolog A

UniProt Gene Name

NSMCE4A

UniProt Synonym Gene Names

C10orf86; NS4EA; Non-SMC element 4 homolog A

UniProt Entry Name

NSE4A_HUMAN

NCBI Protein Information

non-structural maintenance of chromosomes element 4 homolog A

UniProt Comments for NSMCE4A

NSMCE4A: Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus. Belongs to the NSE4 family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 10q26.13

Cellular Component: nucleoplasm

Molecular Function: protein binding

Biological Process: protein sumoylation

Research Articles on NSMCE4A

1. TRIM31 directly binds to NSE4, suggesting the existence of a TRIM31-MAGEA1-NSE4 complex reminiscent of the NSE1-NSE3-NSE4 trimer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with NSMCE4A cdna clone

Products by Pathway	Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Post-translational Protein Modification Pathway antibodies	Post-translational Protein Modification Pathway Diagram
SUMO E3 Ligases SUMOylate Target Proteins Pathway antibodies	SUMO E3 Ligases SUMOylate Target Proteins Pathway Diagram
SUMOylation Pathway antibodies	SUMOylation Pathway Diagram
SUMOylation Of DNA Damage Response And Repair Proteins Pathway antibodies	SUMOylation Of DNA Damage Response And Repair Proteins Pathway Diagram

Diseases associated with NSMCE4A cdna clone

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>1 publications with NSMCE4A and Nervous System Diseases

Organs/Tissues associated with NSMCE4A cdna clone

Organ/Tissue Name	Pubmed Publications
Heart Antibodies	>1 publications with NSMCE4A and Heart